Pyrethroid resistance is becoming widespread in Anopheles gambiae mosquitoes, coinciding with expanded use of insecticide-treated nets (ITNs) throughout Africa. To investigate whether nets in use are still protective, we conducted household trials in northern and southern Benin, where An. gambiae mosquitoes are susceptible and resistant, respectively, to pyrethroids. Rooms were fitted with window traps and monitored for mosquito biting and survival rates before and after the nets were treated with pyrethroid. Sleeping under an ITN in the location with resistant mosquitoes was no more protective than sleeping under an untreated net, regardless of its physical condition. By contrast, sleeping under an ITN in the location with susceptible mosquitoes decreased the odds of biting by 66%. ITNs provide little or no protection once the mosquitoes become resistant and the netting acquires holes. Resistance seriously threatens malaria control strategies based on ITN.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376816 | PMC |
| http://dx.doi.org/10.3201/eid1807.120218 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A systematic review of interventions targeting .
Wellcome Open Res
December 2024
Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
Background: , a malaria mosquito originally from South Asia and the Middle East, has been expanding across both Asia and Africa in recent decades. The invasion of this species into sub-Saharan Africa is of particular concern given its potential to increase malaria burden, especially in urban environments where thrives. Whilst surveillance of this vector in Africa has recently increased markedly there is a need to review the existing methods of control so that we can stop, rather than simply monitor, its spread in Africa.
View Article and Find Full Text PDFPredictors of insecticide-treated nets utilization among children under five years in refugee settlements in Uganda: analysis of the 2018-2019 Uganda Malaria Indicator Survey.
Malar J
January 2025
Department of Geography, Geo-Informatics and Climatic Sciences, Makerere University, P.O Box 7062, Kampala, Uganda.
Background: Despite significant distribution of insecticide-treated net (ITNs) by the Government of Uganda to refugees, malaria is major cause of mortality and morbidity among children under five years in refugee settlements. This highlights the persistent challenges and complexities surrounding malaria control and prevention efforts in these settings. Studies that focus on the determinants of ITN utilization among children under five years in refugee settlements in Uganda are not available.
View Article and Find Full Text PDFMalaria and associated factors among under-five children in Borena pastoral communities, southern Ethiopia.
Front Parasitol
August 2024
School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia.
Background: Malaria continues to be an important threat to public health and infects millions of children under 5 years of age each year. Although Ethiopia has set targets for at-risk group interventions to eradicate and manage malaria, the illness is still a serious public health problem in areas where it is endemic, especially in the unique lowlands in the Borena zone.
Objective: This study aimed to determine the prevalence of malaria and associated factors among children in Borena's pastoral communities, Oromia Regional State, southern Ethiopia, in 2022.
Larviciding for malaria control and elimination in Africa.
Malar J
January 2025
RBM Partnership Vector Control Working Group, Chem du Pommier 40, 1218, Le Grand-Saconnex, Switzerland.
Background: Global progress toward malaria elimination and eradication goals has stagnated in recent years, with many African countries reporting increases in malaria morbidity and mortality. Insecticide-treated nets and indoor residual spraying are effective, but the emergence and increased intensity of insecticide resistance and the challenge of outdoor transmission are undermining their impact. New tools are needed to get back on track towards global targets.
View Article and Find Full Text PDFMalaria survey data and geospatial suitability mapping for understanding spatial and temporal variations of risk across Kenya.
Parasite Epidemiol Control
February 2025
ITC Faculty Geo-Information Science and Earth Observation, University of Twente, Enschede, the Netherlands.
Malaria remains a public health concern in Kenya where children and pregnant women are vulnerable groups. The common interventions in place to fight malaria include using insecticide-treated bed nets (ITNs), knowledge and awareness about malaria, and intake of malaria anti-malaria drugs. Despite the availability of these interventions, Kenya still records more than 10,000 clinical cases annually.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!