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Early-life adversity as a predictor of fibromyalgia syndrome: the central role of perceived stress over endocrine stress indicators.
Pain
January 2025
Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
This study investigates the associations between early childhood adversities, stress perception, and fibromyalgia syndrome (FMS). Although the interconnection between dysregulated stress systems and FMS is well documented, the interconnection between early adversities and FMS remains less understood. This study explores the relationship of early-life stress and FMS by examining its mediation through perceived stress, and acute and chronic endocrine stress indicators.
View Article and Find Full Text PDFMechanisms of Cancer-Induced Bone Pain.
J Pain Res
January 2025
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Bone is a common site of advanced cancer metastasis, second only to the lungs and liver. Cancer-induced bone pain (CIBP) is a persistent and intense pain that is caused by a combination of inflammatory and neuropathic factors. As CIBP progresses, the degree of pain intensifies.
View Article and Find Full Text PDFTranscutaneous Electrical Nerve Stimulation and Aerobic Exercise for Alcohol-Related Peripheral Neuropathy: A Case Report.
Cureus
December 2024
Department of Rehabilitation Medicine, Kyoto University Graduate School of Medicine, Kyoto, JPN.
Alcohol use disorders can cause peripheral and central neurological disorders with symptoms such as pain, numbness, paresthesia, and dysesthesia, often impairing walking ability. However, effective treatments for alcohol-related peripheral neuropathy are yet to be identified. This case report highlights the successful use of dysesthesia-matched transcutaneous electrical nerve stimulation (DM-TENS) and aerobic exercise in a 53-year-old woman with alcohol-related peripheral neuropathy who presented with severe pain and walking difficulties.
View Article and Find Full Text PDFTherapeutic Efficacy of Intranasal -Acetyl-L-Cysteine with Cell-Penetrating Peptide-Modified Polymer Micelles on Neuropathic Pain in Partial Sciatic Nerve Ligation Mice.
Pharmaceutics
January 2025
Laboratory of Pharmacology, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi 274-8555, Japan.
: We previously demonstrated that the intranasal administration of cell-penetrating Tat peptide-modified carrier, PEG-PCL-Tat, improves drug delivery to the central nervous system. This study aimed to evaluate the potential of the post-onset intranasal administration of -acetyl-L-cysteine (NAC) combined with PEG-PCL-Tat (NAC/PPT) for neuropathic pain. : Neuropathic pain was induced by partial sciatic nerve ligation (PSNL) in mice.
View Article and Find Full Text PDFClassifying Low Back Pain Through Pain Mechanisms: A Scoping Review for Physiotherapy Practice.
J Clin Med
January 2025
Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40136 Bologna, Italy.
Low back pain (LBP) is a leading cause of disability worldwide, often driven by distinct pain mechanisms: nociceptive, neuropathic, and central sensitization. Accurate classification of these mechanisms is critical for guiding effective, targeted treatments. A scoping review was conducted following the Joanna Briggs Institute methodology and reported according to PRISMA-ScR guidelines.
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