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In vitro effects of recombinant human Neuritin on hair cell recovery post-gentamicin injury in SC lineage-tracing models: Involvement of notch and FGFR signaling.
Neurochem Int
January 2025
School of Public Health, Hangzhou Normal University, Hangzhou, 311121, PR China. Electronic address:
Hair cell (HC) loss, frequently induced by ototoxic agents such as gentamicin, leads to irreversible hearing loss. Because of the restricted regenerative capabilities of the mammalian inner ear, the exploration of therapeutic strategies to restore damaged HCs is critically needed. Recombinant human Neuritin (rhNeuritin), a neurotrophic factor with established roles in promoting cell survival and regeneration across various systems, presents itself as a promising therapeutic candidate for HC repair.
View Article and Find Full Text PDFVertigo is a common symptom of various diseases that affects a large number of people worldwide. Current leading treatments for intractable peripheral vertigo are to intratympanically inject ototoxic drugs such as gentamicin to attenuate the semicircular canal function but inevitably cause hearing injury. Photodynamic therapy (PDT) is a noninvasive therapeutic approach by precisely targeting the diseased tissue.
View Article and Find Full Text PDFIntra-articular injection of vancomycin after arthrotomy closure following gentamicin-impregnated bone cementation in primary total knee arthroplasty provides a high intra-articular concentration while avoiding systemic toxicity: a prospective study.
J Orthop Surg Res
December 2024
Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China.
Background: This study aimed to elucidate the safety and intra-articular elution profiles of vancomycin and gentamicin bone cement in patients undergoing primary total knee arthroplasty (TKA), with a focus on serum safety thresholds and therapeutic efficacy.
Methods: Consecutive patients who underwent unilateral primary TKA were prospectively enrolled. The implants were fixed using gentamicin-impregnated bone cement, and after arthrotomy closure, 1000 mg of vancomycin suspended in 25 mL of normal saline was directly injected into the joint.
Impact of repeated intranasal gentamicin irrigation on auditory brainstem evoked potentials in rats.
Exp Brain Res
December 2024
Department of Anatomy, Lake Erie College of Osteopathic Medicine, 1858 West Grandview Blvd Erie, Erie, PA, 16504, USA.
Gentamicin is a bactericidal aminoglycoside antibiotic that broadly targets Gram-negative microbes. Both human and animal studies have shown that administration of gentamicin is ototoxic by several routes of administration and results in sensorineural hearing loss due to damaged hair cell at the base of the cochlea. However, gentamicin is also administered intranasally to treat sinusitis in humans, but no animal studies have examined ototoxicity of gentamicin administered via this route.
View Article and Find Full Text PDFMultiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action.
Front Neurol
November 2024
Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA, United States.
Article Synopsis
- Mechanosensory hair cells in the inner ear and lateral line of vertebrates are highly vulnerable to damage, leading to hearing and balance issues, particularly from toxic agents like aminoglycoside antibiotics and certain cancer drugs.
- Exposure to neomycin causes rapid hair cell death within an hour, while gentamicin results in delayed death, which can take up to 24 hours.
- The study identifies two different cellular mechanisms for hair cell death: acute death involves mitochondrial calcium changes and can be treated with certain antioxidants, while delayed death relates to lysosomal issues and may be mitigated by modifying endolysosomal function.
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