AI Article Synopsis
- Aminoglycoside antibiotics can cause serious ear damage (ototoxicity), especially in patients with kidney problems, with risk levels reaching up to 60%.
- Oxidative stress is thought to be a key factor contributing to this ear damage, particularly among individuals undergoing dialysis.
- N-acetylcysteine (NAC) is a safe and effective antioxidant that could potentially protect dialysis patients from aminoglycoside-related ototoxicity, supporting recommending its use for these patients.
Article Abstract
Use of aminoglycoside antibiotics is associated with significant ototoxicity, especially on patients with decreased renal function. The risk of aminoglycoside ototoxicity may approach 60%. Oxidative stress has been suggested as a general mechanism of aminoglycoside ototoxicity and is prevalent in dialysis population. N-acetylcysteine (NAC) is an effective antioxidant and has been safely used in dialysis patients. New experimental and clinical data, explored in this review, provide a good case to recommend NAC administration to all dialysis patients, receiving aminoglycosides.
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| http://dx.doi.org/10.1111/j.1525-139X.2012.01090.x | DOI Listing |
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