AI Article Synopsis
- The study evaluated HBV markers to assess reactivation risk and focus on occult infections in patients at a hematology and transfusion center.
- Out of 468 patients, HBsAg was found in 16 patients, while 21% were positive for anti-HBc, indicating past or ongoing infection.
- Occult HBV infection was identified in roughly 6% of patients, with most of these individuals showing protective antibody levels (anti-HBs).
Article Abstract
The study assessed the incidence of HBV markers (HBsAg, anti-HBc, anti-HBs) important for determination of the risk of reactivation of infection, with particular interest of occult infection (presence of HBV DNA in the absence of HBsAg) in patients treated at the Institute of Hematology and Transfusion Medicine. Anti-HBc frequency was correlated with the age and sex of patients. HBsAg was detected in 16/468 examined patients, 98/468 (21%) were anti-HBc positive. HBV DNA was detected in 41/98 anti-HBc positives; in 13 simultaneously with HBsAg. 28 patients had occult HBV infection (HBV DNA+/HBsAg). Antibody to HBsAg was detected in 163/430 (38%) patients, 81 out of them on protective level (> 100 IU/l). It was shown that occult HBV infection occurs in approximately 6% of patients. In most of them the protective levels of anti-HBs are detected.
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