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Diabetes-related foot disease: new insights with an antipodean focus.
J Endocrinol
June 2023
Central Clinical School, Sydney Medical School, the Faculty of Medicine and Health, University of Sydney and Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Diabetes-related foot disease (DFD), defined as ulceration, infection or destruction of tissues of the foot in a person with current or previously diagnosed diabetes mellitus, is associated with a heavy burden for both patients and the healthcare system with high morbidity, mortality and costs. Improved outcomes for people with DFD are achieved with an interdisciplinary approach and adherence to best practice clinical guidelines; however, in the Australian context, the vastness of the country presents unique challenges in achieving optimal outcomes for all people with DFD, with variation in service delivery, availability and accessibility between metropolitan, rural and remote areas. Aboriginal and Torres Strait Islander Australians and people with diabetes living in rural and remote areas experience higher rates of lower-extremity amputation, and further efforts and resources are required to improve outcomes for these high-risk groups.
View Article and Find Full Text PDFParasite loss or parasite gain? Story of nematodes in antipodean waters.
Parasite Epidemiol Control
February 2019
School of Animal and Veterinary Sciences, Graham Centre for Agricultural Innovations, Charles Sturt University, Australia.
spp. are parasitic nematodes belonging to the family Anisakidae. They are known to be able to have highly pathogenic impacts on both wildlife (fish, birds, marine mammals) and humans.
View Article and Find Full Text PDFSuppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.
Front Immunol
November 2017
Infection Immunology, Research Center Borstel, Borstel, Germany.
Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages become extremely prone to an IL-6-dependent expression of arginase-1 (Arg1) and nitric oxide synthase (NOS)2, the prototype markers for alternative or classical macrophage activation, respectively. Because both enzymes are antipodean macrophage effector molecules in () infection, we assessed the relevance of SOCS3 for macrophage activation during experimental tuberculosis using macrophage-specific SOCS3-deficient (LysMSOCS3) mice.
View Article and Find Full Text PDFMitoQ--a mitochondria-targeted antioxidant.
IDrugs
June 2007
National Research Council, Institute for Biological Sciences, Synaptic Pathophysiology Group, Ottawa, ON K1A 0R6, Canada.
MitoQ is an orally active antioxidant that has the ability to target mitochondrial dysfunction. The agent is currently under development by Antipodean Pharmaceuticals Inc in phase II clinical trials for Parkinson's disease and liver damage associated with HCV infection. MitoQ has demonstrated encouraging preclinical results in numerous studies in isolated mitochondria, cells and tissues undergoing oxidative stress and apoptotic death.
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