The MixAlco™ process biologically converts biomass to carboxylate salts that may be converted to a variety of chemicals and fuels. This study examines the fermentation performance of six different mixed cultures, and how the performance was affected by the bacterial composition of each community. All six countercurrent fermentations had very similar performance, but were dissimilar in microbial community composition. The acid concentrations varied by only 12% between fermentation trains and the conversions varied only by 6%. The microbial communities were profiled using 16S rRNA tag-pyrosequencing, which revealed the presence of dynamic communities that were dominated by bacteria resembling Clostridia, but they shared few taxa in common. Yue-Clayton similarity calculations of the communities revealed that they were extremely different. The presence of different but functionally similar microbial communities in this study suggests that it is the operating parameters that determine the fermentation end-products.
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http://dx.doi.org/10.1016/j.biortech.2012.05.043 | DOI Listing |
Sleep Health
January 2025
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Objectives: To describe sleep duration, adherence to sleep recommendations, and behavioral and sociodemographic correlates of sleep among Samoan children.
Methods: In a longitudinal cohort study of Samoan children aged 2-9years (n = 481; 50% female), primary caregivers reported usual number of hours of nighttime sleep during 2015, 2017/2018, and 2019/2020 data collection waves. Associations between behavioral and sociodemographic characteristics and sleep duration were assessed using generalized linear and mixed effect regressions.
J Food Drug Anal
December 2024
Division of Research and Analysis, Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan, R.O.C.
Limosilactobacillus reuteri is a probiotic bacterium known for its numerous beneficial effects on human health and is commonly utilized in various dietary supplements. Previously, we encountered difficulties in isolating L. reuteri from retail dietary supplements containing complex probiotic compositions by using non-selective media such as de Man, Rogosa, and Sharpe (MRS) agar.
View Article and Find Full Text PDFJMIR Med Inform
January 2025
Sungkyunkwan University, Seoul, Republic of Korea.
Background: Mental health chatbots have emerged as a promising tool for providing accessible and convenient support to individuals in need. Building on our previous research on digital interventions for loneliness and depression among Korean college students, this study addresses the limitations identified and explores more advanced artificial intelligence-driven solutions.
Objective: This study aimed to develop and evaluate the performance of HoMemeTown Dr.
Alzheimers Dement
December 2024
University of Alabama at Birmingham, Birmingham, AL, USA.
Progranulin is a secreted pro-protein that is necessary for maintaining lysosomal function and exerts anti-inflammatory and neurotrophic effects in the brain. Loss-of-function GRN mutations, most of which cause progranulin haploinsufficiency, are a major autosomal dominant cause of frontotemporal dementia (FTD). Other GRN variants are associated with risk for FTD, Alzheimer's disease (AD) and Parkinson's disease.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Background: Maintaining synaptic health is essential for normal neurological function, yet neurodegenerative diseases like Alzheimer's disease and Progressive Supranuclear Palsy (PSP) exhibit synaptic loss. In these conditions, synaptic loss precedes neuronal degeneration, and the degree of synaptic loss correlates closely with the severity of clinical symptoms. Both Aβ, which accumulates in amyloid plaques in AD, and tau protein which accumulates intracellularly in tauopathies, including AD and PSP, accumulate within synaptic terminals.
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