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Adipose-derived stem cell exosomes attenuates myofibroblast transformation via inhibiting autophagy through TGF-β/Smad2 axis in oral submucosal fibrosis.
J Nanobiotechnology
December 2024
Department of Oral & Maxillofacial Surgery, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The transformation of fibroblasts to myofibroblast is the key pathological change in the development of OSF.
View Article and Find Full Text PDFCurcumin Alleviates Arecoline-induced Oral Submucous Fibrosis via the FOSL1/MAPK8 Axis.
Cell Biochem Biophys
December 2024
Department of Periodontal Mucosa, Changsha Stomatological Hospital, Changsha, Hunan, 410004, P.R. China.
Oral submucous fibrosis (OSF) is a precancerous lesion of the oral cavity. Areca nut consumption can cause OSF through sustained activation of buccal mucosal fibroblasts (BMFs). This study explored the effect of curcumin on arecoline-induced BMF activation and its mechanism of action.
View Article and Find Full Text PDFOral health status among lorry drivers in Hyderabad city - A cross sectional study.
Work
December 2024
Optum Technological Solutions, Hyderabad, India.
Background: Lorry drivers work tirelessly behind the wheels, commuting from one place to another without regular and adequate food, rest and sleep. These people often have odd working hours, long work shifts with frequent changes to their work schedule. In addition, they work in unfavorable climate conditions and face variety of problems like traffic congestions, vehicle fumes, vibrations and poor conditions of roads.
View Article and Find Full Text PDFEpidemiology of quid usage and its possible association with the occurrence of oral mucosal lesions.
Front Oral Health
November 2024
Department of Oral Medicine and Radiology, Vyas Dental College and Hospital, Jodhpur, India.
Article Synopsis
- Chewing tobacco use is a significant public health concern in India, especially linked to the rising rates of oral cancer among young adults.
- A study involving 1,209 patients revealed a high prevalence of chewing tobacco, particularly among men aged 26-35, with many consuming it frequently throughout the day.
- The study concluded that chewing tobacco is closely associated with oral mucosal lesions, highlighting the need for public health efforts to change cultural attitudes and enforce stricter regulations against tobacco use.
Comparative Evaluation of Low-level Laser Therapy and Intralesional Injection in OSMF Patients: A Quasi-randomized Trial.
J Contemp Dent Pract
August 2024
Department of Oral and Maxillofacial Surgery, Malabar Dental College and Research Centre, Manoor, Edappal, Malappuram, Kerala, India.
Aim: The aim of the present study was to compare the effectiveness of low-level laser therapy and intralesional injection in oral submucous fibrosis (OSMF) patients.
Materials And Methods: The present study comprised of 52 grade II OSMF patients aged between 20 and 60 years. A pretreatment assessment was done for each patients.
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