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Clinicopathologic Correlation and Routine Immunostains Help Distinguish Congenital Disseminated Pyogenic Granuloma From Other Cutaneous Disseminated Vascular Proliferations of Infancy: Case Report and Literature Review.
Am J Dermatopathol
December 2024
Dartmouth-Hitchcock Medical Center, Department of Pathology and Laboratory Medicine, Lebanon , NH.
Article Synopsis
- - The presence of multiple skin lesions in infants may indicate underlying health issues, requiring dermatopathologists to differentiate between conditions that have different treatment outcomes.
- - The article focuses on three rare conditions: congenital disseminated pyogenic granuloma, multifocal infantile hemangioma, and multifocal lymphangioendotheliomatosis with thrombocytopenia, highlighting how to distinguish them using histopathology and immunohistochemistry.
- - A case study is presented about an infant with congenital disseminated pyogenic granuloma affecting both skin and liver, showing that the lesions can resolve naturally over time without treatment, which underscores the importance of diagnosis and monitoring.
Multifocal lymphangioendotheliomatosis with thrombocytopenia: Report of a case with favorable outcome into adulthood.
JAAD Case Rep
July 2024
Department of Dermatology, Faculty of Medicine Lyon-Est, Edouard Herriot Hospital, Lyon, France.
A Case of Multifocal Lymphangioendotheliomatosis With Thrombocytopenia and Changes in Coagulopathy.
J Pediatr Hematol Oncol
April 2023
Department of Pediatrics.
Article Synopsis
- Multifocal lymphangioendotheliomatosis with thrombocytopenia is a rare disease marked by multiple vascular lesions and low platelet counts (thrombocytopenia) that complicate diagnosis due to varied symptoms.
- A case study of a male infant revealed severe thrombocytopenia linked to local inflammation, along with swollen extremities and soft tissue/bone involvement, but no gastrointestinal bleeding.
- Treatment with sirolimus and prednisolone successfully resolved the thrombocytopenia, and elevated levels of plasma angiopoietin-2 may serve as a helpful biomarker for this condition.
Successful Treatment With Everolimus for Multifocal Lymphangioendotheliomatosis With Thrombocytopenia in an Infant.
J Pediatr Hematol Oncol
March 2023
Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is a rare disease characterized by the presence of multiple cutaneous lesions and bleeding from the gastrointestinal tract with thrombocytopenia. Because of the varied phenotypes and rarity of MLT, a treatment strategy has not been standardized thus far. We describe a case of infantile MLT that did not respond to treatment with propranolol, prednisolone, or vincristine.
View Article and Find Full Text PDFIntroduction: Multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT) is characterized by multiple maculopapular lesions involving the stomach and the lungs, associated with thrombocytopenia as a result of platelet entrapment. Episodes of severe digestive bleeding, which are sometimes unmanageable, are one of its most frequent presentations and a cause of mortality. Our objective was to describe the various phenotypes, as well as our treatment experience.
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