AI Article Synopsis
- A novel one-step method synthesizes a curcumin-based hydrogel with curcumin content ranging from 25-75 mol%, using biodegradable linkages to keep the curcumin stable.
- The hydrogel shows varying physical properties like water absorption (100-550%) and compression strength (7-100 kPa), with the ability to release curcumin over a period of up to 80 days.
- In vitro studies indicate that these hydrogels are selectively toxic to breast cancer cells while being non-toxic to healthy skin cells, suggesting potential use in soft tissue reconstruction post-cancer surgery.
Article Abstract
A one-step synthesis of a curcumin-derived hydrogel (curcumin content of 25-75 mol %) is reported. Curcumin is incorporated into the hydrogel backbone and cross-linked through biodegradable carbonate linkages. Curcumin as a part of the polymer backbone is protected from oxidation and degradation, while hydrogel hydrolysis results in the release of active curcumin. Nontoxic poly(ethylene glycol) and desaminotyrosyl-tyrosine ethyl ester are used to tune the hydrophilic/hydrophobic hydrogel properties. In this way, hydrogels with a wide range of physical properties including water-uptake (100-550%) and compression moduli (7-100 kPa) were obtained. Curcumin release is swelling-controlled and could be extended to 80 days. In vitro, curcumin-derived hydrogels showed selective cytotoxicity against MDA-MB-231 (IC(50) 9 μM) breast cancer cells but no cytotoxicity to noncancerous quiescent human dermal fibroblasts even at high curcumin concentrations (160 μM). One possible application of these curcumin-derived hydrogels is as soft tissue filler after surgical removal of cancerous tissue.
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| http://dx.doi.org/10.1021/bm300518e | DOI Listing |
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Article Synopsis
- A novel one-step method synthesizes a curcumin-based hydrogel with curcumin content ranging from 25-75 mol%, using biodegradable linkages to keep the curcumin stable.
- The hydrogel shows varying physical properties like water absorption (100-550%) and compression strength (7-100 kPa), with the ability to release curcumin over a period of up to 80 days.
- In vitro studies indicate that these hydrogels are selectively toxic to breast cancer cells while being non-toxic to healthy skin cells, suggesting potential use in soft tissue reconstruction post-cancer surgery.
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