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Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease. | LitMetric

Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease.

Expert Rev Clin Pharmacol

Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA.

Published: May 2012

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity globally, and its development is mainly associated with tobacco/biomass smoke-induced oxidative stress. Hence, targeting systemic and local oxidative stress with agents that can balance the antioxidant/redox system can be expected to be useful in the treatment of COPD. Preclinical and clinical trials have revealed that antioxidants/redox modulators can detoxify free radicals and oxidants, control expression of redox and glutathione biosynthesis genes, chromatin remodeling and inflammatory gene expression; and are especially useful in preventing COPD exacerbations. In this review, various novel approaches and problems associated with these approaches in COPD are reviewed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376391PMC
http://dx.doi.org/10.1586/ecp.12.16DOI Listing

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