For nurse educators teaching about policies, choosing an interactive approach is vital. One such method is a mock trial. This article describes the process to present a mock trial to emphasize the importance of documenting critical values. This strategy emphasizes learner participation and offers a real-life scenario in a safe, simulated environment.
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy.
Exp Hematol Oncol
January 2025
Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Background: Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered chimeric Fcγ receptor (FcγR) T cells and tested their potential as a versatile platform for universal T cell therapy.
Methods: Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64.
"Just-in-time" but a bit delayed: Personalizing digital nudges for healthier online food choices.
Appetite
January 2025
Tilburg University, Department of Communication & Cognition, P.O. Box 90153, 5000 LE, Tilburg, the Netherlands. Electronic address:
As food choices are increasingly made in contexts such as online supermarkets, nudging has been extrapolated to the digital sphere. Digitalization poses unique opportunities to enhance the promotion of healthier food choices online: Digital nudges can be delivered "just-in-time" (JIT), in response to the initial selection of an unhealthy product. Furthermore, digital JIT nudges can be personalized to match user characteristics of behavioral relevance, such as one's food and cognitive processing preferences.
View Article and Find Full Text PDFSingle immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial.
Nat Med
January 2025
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Malaria vaccines consisting of metabolically active Plasmodium falciparum (Pf) sporozoites can offer improved protection compared with currently deployed subunit vaccines. In a previous study, we demonstrated the superior protective efficacy of a three-dose regimen of late-arresting genetically attenuated parasites administered by mosquito bite (GA2-MB) compared with early-arresting counterparts (GA1-MB) against a homologous controlled human malaria infection. Encouraged by these results, we explored the potency of a single GA2-MB immunization in a placebo-controlled randomized trial.
View Article and Find Full Text PDFNational Institute of Neurological Disorders and Stroke Clinical Trials Methodology Course: Summary and Accomplishments 2014-2023.
Neurol Educ
December 2024
From the Department of Neurology (M.Q.), University of Virginia, Charlottesville; Department of Neurology (L.G., R.A.C.), Indiana University, Indianapolis; Department of Biostatistics (C.S.C.), University of Iowa, Iowa City; The Lunquist Institute (R.J.L.), Torrance, CA; and Departments of Emergency Medicine (C.M., W.J.M.), and Neurology (W.J.M.), University of Michigan, Ann Arbor.
The Clinical Trials Methodology Course (CTMC), given from 2014 to 2023, was conducted to educate early-career clinical investigators from various backgrounds in neurosciences in the design of clinical trials and to provide mentorship to enhance academic careers and retention plus improve research productivity and the likelihood of successful grant applications. This summary describes the rationale, history, structure, and trainee outcomes of the CTMC. The course used small groups, consisting of 1-2 clinical faculty advisor(s), 1 faculty biostatistician, and 2-4 trainees who met remotely approximately weekly over 12 weeks.
View Article and Find Full Text PDFThe Role of Complainant/Defendant Gender and Form of Sexual Assault on Jurors' Perceptions of Prototypicality and Verdicts.
J Interpers Violence
February 2025
Department of Psychology, Carleton University, Ottawa, ON, Canada.
We sought to test the effects of sexual assault form and complainant/defendant gender on jurors' perceptions of the prototypicality of a sexual assault case, complainant, and defendant. We examined whether these perceived prototypicality measures predict mock jurors' complainant/defendant blame and credibility assessments and if these assessments predict verdict decisions in a simulated sexual assault trial. We predicted that the female complainant-male defendant condition, vaginal intercourse condition, and their combination would be perceived as more prototypical than their counterparts, which would predict blame/credibility assessments, ultimately predicting verdict.
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