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Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion.
Heliyon
December 2024
Department of Obstetrics and Gynaecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Recurrent spontaneous abortion (RSA) is intricately linked to metabolic dysregulation at the maternal-fetal interface during early gestation. Abnormal levels of essential fatty acids and downstream oxylipins in decidua and chorionic villi have been identified as potential risk factors for RSA. Oxylipins have been linked to excessive inflammation, which might disrupt maternal-fetal immune tolerance, potentially contributing to RSA.
View Article and Find Full Text PDFUmbilical vein remodeling is associated with pregestational maternal overweight.
Front Endocrinol (Lausanne)
December 2024
Institute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, Brazil.
Introduction: Excess weight during pregnancy is a condition that can affect both mother and fetus, through the maternal-fetal interface, which is constituted by the placenta and umbilical cord. The umbilical vein is responsible for transporting oxygen and nutrients to the fetus, and its proper functioning depends on the integrity of its structure. The remodeling of the umbilical vein represents one of the causes of inadequate transport of nutrients to the fetus, being potentially harmful.
View Article and Find Full Text PDFManipulation of ion/electron carrier genes in the model diatom enables its growth under lethal acidic stress.
iScience
August 2024
Ocean College, Zhejiang University, Zhoushan, Zhejiang 316021, China.
A major obstacle to exploiting industrial flue gas for microalgae cultivation is the unfavorable acidic environment. We previously identified three upregulated genes in the low-pH-adapted model diatom : ferredoxin (PtFDX), cation/proton antiporter (PtCPA), and HCO transporter (PtSCL4-2). Here, we individually overexpressed these genes in to investigate their respective roles in resisting acidic stress (pH 5.
View Article and Find Full Text PDFInflammatory Pathways of Sulfonamide Diuretics: Insights into SLC12A Cl Symporters and Additional Targets.
Cell Physiol Biochem
January 2025
Department of Pharmacology and Toxicology, Wright State University, School of Medicine. Dayton, Ohio, United States,
Thiazide, thiazide-like, and loop diuretics are primarily known for inhibiting members of the SLC12A family of Cl transporters, which include the Na+Cl cotransporter (NCC), NaK2Cl cotransporters (NKCC1 and NKCC2) and KCl symporters (KCC1-4). While the main pharmacological effect of these diuretics is diuresis, achieved by promoting the excretion of excess water and salt through the kidneys, they have intriguing pharmacological effects beyond their traditional ones which cannot be solely attributed to their effects on renal salt transport. Of particular interest is their role in modulating inflammatory processes.
View Article and Find Full Text PDFGenotypic difference in response to copper stress in upland cotton as revealed by physiological and molecular expression analyses.
BMC Plant Biol
January 2025
Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Ministry of Education, College of Agronomy, Jiangxi Agricultural University, Nanchang, 330045, China.
Background: Cotton is a non-edible fiber crop with considerable potential for the remediation of copper-polluted soil. However, the Cu toxicity tolerance mechanism in cotton remains largely obscure. To address the issue, we first identified two cotton lines contrasting in response to Cu toxicity by examining 12 morphological and physiological attributes of 43 origin scattered cotton genotypes under Cu excess.
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