AI Article Synopsis
- The study evaluates the effectiveness of pegylated interferon combined with ribavirin in treating HIV and hepatitis C virus genotype 4 (HCV-4) coinfected patients.
- A total of 31.5% of HCV-4 patients achieved a sustained virological response (SVR), which is statistically better compared to 22.7% in those with hepatitis C genotype 1.
- The IL28B CC genotype is identified as a significant predictor for achieving SVR in HIV/HCV-4-coinfected patients.
Article Abstract
We assess the efficacy of pegylated interferon (peg-IFN) with ribavirin (RBV) and the predictors of sustained virological response (SVR) among HIV/hepatitis C virus genotype 4 (HCV-4)-coinfected patients. Thirty-nine (31.5%) of 124 individuals with HCV-4 achieved SVR compared with 103 (22.7%) of 453 individuals with HCV genotype 1 (P=0.046). Only interleukin-28B (IL28B) genotype CC was independently associated with SVR in HIV/HCV-4-coinfected patients. The efficacy of peg-IFN with RBV in coinfected individuals with genotype 4 is significantly higher than in those with genotype 1. IL28B CC genotype is the main predictor of response in this population.
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| http://dx.doi.org/10.1097/QAD.0b013e3283568884 | DOI Listing |
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