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The CREscendoing promise of HDAC targeting to limit atherosclerosis.
Immunity
March 2025
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. Electronic address:
The factors that modulate the inflammatory response in atherosclerosis are not well defined. In this issue of Immunity, Asare et al. examine the impact of a cis-regulatory element (CRE) that controls expression of HDAC9 and find that HDAC9-mediated deacetylation of NLRP3 might be the mechanism by which genetic variants in this conserved CRE influence the inflammation associated with human atherosclerosis.
View Article and Find Full Text PDFA paradigm shift in stomatal regulation: HS as a persulfidation-driven modulator of potassium channels.
J Integr Plant Biol
March 2025
Co-Innovation Center for Sustainable Forestry in Southern China, State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation, College of Life Sciences, Nanjing Forestry University, Nanjing, 210037, China.
This commentary on Liu et al. (2025 JIPB) discusses the groundbreaking discovery that hydrogen sulfide (HS) modulates guard cell function by inhibiting inward-rectifying potassium channels through protein persulfidation, providing novel insights into the molecular mechanisms governing stomatal regulation and opening new avenues for enhancing plant stress resilience.
View Article and Find Full Text PDFFear conditioning: Insights into learning, memory and extinction and its relevance to clinical disorders.
Prog Neuropsychopharmacol Biol Psychiatry
March 2025
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany; Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:
Fear, whether innate or learned, is an essential emotion required for survival. The learning, and subsequent memory, of fearful events enhances our ability to recognise and respond to threats, aiding adaptation to new, ever-changing environments. Considerable research has leveraged associative learning protocols such as contextual or auditory forms of fear conditioning in rodents, to understand fear learning, memory consolidation and extinction phases of memory.
View Article and Find Full Text PDFWe discuss the study by Uğur Bezirgan et al., titled "Comparison of Locking Plate and Conservative Treatment in Elderly Patients with Displaced Proximal Humerus Fractures." The authors are commended for their prospective study, which offers valuable insights into the comparison of locking plate fixation and conservative treatment.
View Article and Find Full Text PDFPersistent Pelvic Floor Dysfunction in Female Athletes: A Commentary on Postconservative Management.
Curr Sports Med Rep
March 2025
Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, United Kingdom.
Pelvic floor dysfunction is still an undervalued, underreported, and undertreated condition among female athletes. Despite high prevalence rates and growing interest within the scientific community, significant gaps persist in the application of evidence-based practices in sports medicine. This commentary, inspired by real questions encountered in the authors' work, is presented in a Q&A format to simulate a realistic conversation.
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