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Differentiation of Cholinergic Neurons in Rat Spinal Cord Under Conditions of Allotransplantation into a Peripheral Nerve and In Situ Development.
Bull Exp Biol Med
November 2015
Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology, Institute of Experimental Medicine, St. Petersburg, Russia.
The method of ectopic transplantation of embryonic anlages of CNS allows studying histoblastic potencies of progenitor cells developing under conditions of changed microenvironment. Some progenitor cells in the transplants of rat embryonic spinal cord retained their ability to express choline acetyltransferase after transplantation into the sciatic nerve of adult animals. Comparative analysis of cholinergic neurons in the neurotransplants and neurons formed in rat spinal cord during normal ontogeny showed that choline acetyltransferase-positive cells after transplantation into the nerve reached morphological differentiation of motor neurons at later terms than cells developing in situ.
View Article and Find Full Text PDF[Immunohistochemical analysis of development of suspension and tissue neurotransplants].
Izv Akad Nauk Ser Biol
February 2012
Engraftment and development of suspension and whole tissue allografts from the mouse brain embryonal tissue, in which cells of the green fluorescent protein (GFP) are synthesized, have been studied. The transgenic mouse cells with synthesized GFP can be used for neurotransplantation. Whole tissue and suspension transplants are able to survive more than 30 days without rejection in the brain of adult mice.
View Article and Find Full Text PDF[The background and evoked neuronal impulse activity of embryonic neurotransplant of somatosensory brain cortex in rats].
Ross Fiziol Zh Im I M Sechenova
May 2005
The investigation was intended for studying the character of the background and evoked impulse activity of embryonic neurotransplant neurons 4 months after homotopical allotransplantation into the barrel field of somatosensory recipient's brain cortex of the rat. It is established, that the current average frequency of background impulse activity of transplant neurons is reduced in comparison with one of the control rats. It is shown that the evoked impulse activity of neurotransplant develops with the long latency than in somatosensory cortex of the control animals.
View Article and Find Full Text PDFHuman brain must not be use for experiments. It is necessary to create new approaches for study of brain developing mechanisms under unfavorable conditions of external and internal environments. One of such approaches is our model of human tissue development study into xenografts.
View Article and Find Full Text PDFEffects of neurotransplants and BDNF on the survival and regeneration of injured adult spinal motoneurons.
Eur J Neurosci
December 1997
Department of Anatomy, Umeå University, Sweden.
We compared the effects of peripheral nerve grafts, embryonic spinal cord transplants and brain-derived neurotrophic factor (BDNF) on the survival and axon regeneration of adult rat spinal motor neurons undergoing retrograde degeneration after ventral root avulsion. Following implantation into the dorsolateral funiculus of the injured spinal cord segment, neither a peripheral nerve graft nor a combination of peripheral nerve graft with embryonic spinal cord transplant could prevent the retrograde motor neuron degeneration induced by ventral root avulsion. However, intrathecal infusion of BDNF promoted long-term survival of the lesioned motor neurons and induced abundant motor axon regeneration from the avulsion zone along the spinal cord surface towards the BDNF source.
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