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The prognostic significance of stress-phenotyping for stroke incidence: the Malmö Diet and Cancer Study.
Stress
December 2025
Technology Transfer and Innovation-Support Office, North-West University, Potchefstroom, South Africa.
Background: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensitive cardiac-troponin-T, and diastolic blood pressure which exemplifies the stress-ischemic-phenotype index.
View Article and Find Full Text PDFIsolation and characterization of methicillin-resistant Staphylococcus aureus from bovine mastitis in North West Cameroon: public health implications.
BMC Res Notes
December 2024
Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Box 63, Buea, Cameroon.
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a zoonotic pathogen that poses a serious threat to veterinary and public health worldwide. We investigated mastitis milk samples for contamination with MRSA and also characterized the MRSA isolates by investigating antimicrobial resistance and virulence factors.
Result: We confirmed MRSA in 69 of 201 (34.
Type 1 diabetes genetic risk score variation across ancestries using whole genome sequencing and array-based approaches.
Sci Rep
December 2024
Department of Clinical and Biomedical Sciences, RILD Building, Royal Devon and Exeter Hospital, University of Exeter, Barrack Road, Exeter, EX2 5DW, UK.
A Type 1 Diabetes Genetic Risk Score (T1DGRS) aids diagnosis and prediction of Type 1 Diabetes (T1D). While traditionally derived from imputed array genotypes, Whole Genome Sequencing (WGS) provides a more direct approach and is now increasingly used in clinical and research studies. We investigated the concordance between WGS-based and array-based T1DGRS across genetic ancestries in 149,265 UK Biobank participants using WGS, TOPMed-imputed, and 1000 Genomes-imputed array genotypes.
View Article and Find Full Text PDFChildhood adversity and peer influence in adolescent bullying perpetration.
Sci Rep
December 2024
Faculty of Humanities, North-West University Mafikeng, Mafikeng, South Africa.
Bullying among South African adolescents is a critical public health issue. This study explores the relationship between childhood adversity, peer influence, and personality traits in predicting bullying perpetration. Data from 769 high school learners were analysed using Structural Equation Modelling.
View Article and Find Full Text PDFSpatiotemporal dynamics of the oropharyngeal microbiome in a cohort of Ivorian school children.
Sci Rep
December 2024
Centre Suisse de Recherches Scientifiques en Côte d'Ivoire (CSRS), Abidjan, Côte d'Ivoire.
The respiratory tract harbours microorganisms of the normal host microbiota which are also capable of causing invasive disease. Among these, Neisseria meningitidis a commensal bacterium of the oropharynx can cause meningitis, a disease with epidemic potential. The oral microbiome plays a crucial role in maintaining respiratory health.
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