Feeling a bit cagey: morpholino-based antisense reagents have been caged through oligonucleotide cyclization, enabling photocontrol of gene expression in zebrafish embryos and larvae. Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas has been examined.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434341PMC
http://dx.doi.org/10.1002/anie.201201690DOI Listing

Publication Analysis

Top Keywords

cyclic caged
4
caged morpholinos
4
morpholinos conformationally
4
conformationally gated
4
gated probes
4
probes embryonic
4
embryonic gene
4
gene function
4
function feeling
4
feeling bit
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!