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Conditionally Activated Cross-Linked crRNAs for CRISPR/Cas12a Based Nucleic Acid Detection.
ACS Synth Biol
January 2025
Beijing National Laboratory for Molecular Sciences (BNLMS), Chinese Academy of Sciences Key Laboratory of Molecular Recognition and Function, Chinese Academy of Sciences Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
CRISPR/Cas systems, particularly CRISPR/Cas12a, have revolutionized nucleic acid detection due to their exceptional specificity and sensitivity. However, CRISPR/Cas12a's cleavage activity can interfere with amplification processes, such as reverse transcription (RT) and isothermal amplification (e.g.
View Article and Find Full Text PDFThink Beyond the Room: Measuring Relative Humidity in the Home Cage and Its Impact on Reproduction in Laboratory Mice, .
Animals (Basel)
November 2024
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Relative humidity (RH) is measured in vivaria with a broad range to accommodate seasonal fluctuations. It is assumed that measurements in the room (macroenvironment) reflect those in the cage (microenvironment). However, there is limited data comparing RH in the macroenvironment to the microenvironment and how the mice may be affected by variations in RH that fall within husbandry recommendations.
View Article and Find Full Text PDFPost-Synthetic Modification of Porous Organic Cages for Enhanced Iodine Adsorption Performance.
Adv Sci (Weinh)
December 2024
Department of Chemistry, Zhejiang University, Hangzhou, 310058, China.
Article Synopsis
- Capturing radioactive iodine from nuclear waste is essential for protecting the environment and human health, and porous organic cages (POCs) show promise for efficient iodine adsorption.
- A new three-step post-synthetic modification (PSM) strategy was developed to enhance a specific POC, resulting in a modified version (OFT-RCC36Br) with improved iodine vapor uptake due to its unique features.
- This PSM strategy has been demonstrated to be applicable to other POCs as well, expanding their functional diversity and potential usage in iodine capture.
Tuning singlet oxygen generation with caged organic photosensitizers.
Nat Commun
September 2024
Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK.
Article Synopsis
- Controlling chemical processes with precision is crucial for areas like biomedical research and drug manufacturing, yet there's a need for universal methods to adjust reactivity in organic photosensitizers.
- This study highlights a new strategy that allows for the fine-tuning of singlet oxygen production using bioresponsive stimuli, demonstrating that photocatalytic activity can be blocked and then activated with various triggers.
- The approach is applicable to a wide range of photosensitizers and can be utilized in practical applications, such as targeted destruction of human cells and enhancing the release of singlet oxygen in the synthesis of natural product drugs.
Multi-Template-Guided Synthesis of High-Dimensional Molecular Assemblies for Humidity Gradient-Based Power Generators.
Angew Chem Int Ed Engl
October 2024
Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Universities of Jilin Province Institute of Functional Material Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun, 130022, China.
Systematically orchestrating fundamental building blocks into intricate high-dimensional molecular assemblies at molecular level is imperative for multifunctionality integration. However, this remains a formidable task in crystal engineering due to the dynamic nature of inorganic building blocks. Herein, we develop a multi-template-guided strategy to control building blocks.
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