This paper reported the effect of Ma-Xin-Shi-Gan tang (Decoction of Herba Ephedrae, Semen Armeniacae Amarum, Radix Glycyrrhizae and Gypsum Fibrosum) on the immune function of the children with acute lower respiratory tract infection (ALRTI). 64 cases of ALRTI children were chosen for clinical observation. Laboratory researches including 7 immune indexes: blood OKT3+ cell, OKT4+ cell, OKT8+ cell and OKT4+/OKT8+ cell ratio, serum IgG, IgA, IgM. Some tests in experimental mice were also made. The results showed: (1) Before treatment, the blood OKT3+ cell, OKT4+ cell and OKT4+/OKT8+ cell ratio of the ALRTI children were lower, OKT8+ cell was higher than that of the normal group, which indicated lowered function of cell mediated immunity (CMI) in ALRTI children. Furthermore, IgM content in serum of the ALRTI children was significantly higher than that of the normal group, which indicated a hyperhumoral immunity (HI). (2) Blood OKT4+ cell and OKT4+/OKT8+ cell ratio in children after treatment with the Decoction were higher than those before treatment, which suggested the Decoction can regulate the cell ratio of OKT4+ and OKT8+, and relieve the functional inhibition of CMI in ALRTI children, while comparing with the western medicine (WM) group, the blood OKT3+ cell, OKT4+ cell and serum IgG content in the Decoction group after treatment were higher. In the WM group, the serum IgG and IgA contents were lower than those of the normal group, which indicated inhibited function of HI after treatment. (3) In experimental mice, the Decoction can increase the phagocytic index of the macrophage, the spleen index and the level of serum hemolysin. It can also enhance the skin delayed allergic reaction of the mice.(ABSTRACT TRUNCATED AT 250 WORDS)
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Int J Mol Sci
December 2024
Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Respiratory syncytial virus (RSV) is one of the most prevalent viruses that causes severe acute lower respiratory tract infections (ALRTIs) in the elderly and young children. There is no specific drug to treat RSV, only a broad-spectrum antiviral, ribavirin, which is only used in critical cases. Our research group is investigating antiviral agents of natural origin, such as coumarins and flavonoids, that may help reduce or prevent RSV infection.
View Article and Find Full Text PDFJ Int Med Res
December 2024
Department of Pediatrics, Jordan University Hospital, Amman, Jordan.
Objectives: To describe changes in respiratory syncytial virus (RSV) epidemiology, its associated clinical outcomes and predictors of severe acute lower respiratory tract infection (ALRTI) pre- and post-COVID-19.
Methods: In this retrospective cohort, we analysed data from electronic medical record of children <5 years who were hospitalized at Jordan University Hospital with RSV-associated ALRTI from 2018 to 2022.
Results: 325 inpatients with respiratory infections were included.
J Med Virol
December 2024
Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Human parainfluenza virus (PIV) is a main cause of acute lower respiratory tract infections (ALRTIs), which contributes to childrens' mortality worldwide; however, the epidemiology of PIVs following the SARS-CoV-2 pandemic is still not clarified, and poses risks of potential outbreaks. Herein, we conducted a retrospective observational study from September 26, 2020 to September 30, 2023 to assess PIV epidemiology in Wuhan, China, as well as the clinical characteristics of PIV infections. In total, 14,065 inpatients with ALRTIs were enrolled, of which 936 were identified to have PIV infection.
View Article and Find Full Text PDFArch Virol
October 2024
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Virol Sin
October 2024
Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing 100045, China. Electronic address:
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