Contractions to 5-hydroxytryptamine in human coronary artery and human saphenous vein.

Br J Clin Pharmacol

Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland.

Published: February 1991

Isometric contractions were obtained to 5-hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5-HT2 receptor antagonist ketanserin, both 5-HT1 and 5-HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5-HT1 receptor.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368106PMC
http://dx.doi.org/10.1111/j.1365-2125.1990.tb05476.xDOI Listing

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