Purpose: The purpose of our study was to evaluate the efficacy of computed-tomography (CT)-guided transthoracic needle biopsy (TNB) and fine needle aspiration (FNA) in diagnosing pulmonary infectious diseases.

Patients And Methods: We retrospectively reviewed the medical records of patients treated at our institution between October 2006 and September 2009 and identified 161 patients who had undergone CT-guided TNB or FNA. We conducted CT-guided TNB or FNA for the patients if bronchoscopy failed to provide proper diagnosis or if their thoracic lesions were not appropriate targets for bronchoscopy.

Results: Twenty-three patients were diagnosed with pulmonary infectious diseases, of whom 17 were diagnosed by CT-guided TNB or FNA; sensitivity was therefore 73.9 % (17/23). The diagnostic rate for Aspergillus infection was especially high (75 %).

Conclusion: CT-guided TNB and FNA proved to be effective as alternative methods if bronchoscopy failed to diagnose pulmonary infectious diseases, with acceptable complication rates.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11604-012-0094-3DOI Listing

Publication Analysis

Top Keywords

pulmonary infectious
16
ct-guided tnb
16
tnb fna
16
ct-guided transthoracic
8
transthoracic needle
8
needle biopsy
8
fine needle
8
needle aspiration
8
bronchoscopy failed
8
infectious diseases
8

Similar Publications

Bovine tuberculosis (BTB) is an infectious disease of livestock and wildlife species that is caused by pathogenic members of the Mycobacterium tuberculosis complex such as Mycobacterium bovis. Due to the introduction of M. bovis-infected bison in the 1920s, BTB is now endemic in wood bison (Bison bison athabascae) population within the Wood Buffalo National Park (WBNP) in northern Canada.

View Article and Find Full Text PDF

Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology.

Discov Oncol

January 2025

Department of Thoracic Surgery, Shanghai Public Health Clinical Center, Fudan University Shanghai, Caolang Highway 2901#, Jinshan District, Shanghai, People's Republic of China.

Background: Lung adenocarcinoma (LUAD) is a leading form of non-small cell lung cancer characterized by a complex tumor microenvironment (TME) that influences disease progression and therapeutic response. Tumor-associated macrophages (TAMs) within the TME promote tumorigenesis and evasion of immune surveillance, though their heterogeneity poses challenges in understanding their roles and therapeutic targeting. Additionally, traditional Chinese medicine (TCM) offers potential anti-cancer agents that could modulate the immune landscape.

View Article and Find Full Text PDF

Uncovering the impact of COVID-19-mediated bidirectional dysregulation of cytochrome P450 3A4 on systemic and pulmonary drug concentrations using physiologically based pharmacokinetic modeling.

Drug Metab Dispos

January 2025

Current affiliation: Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Current affiliation: OneDrug Inc., Toronto, Ontario, Canada; Program in Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada; Centre for Applied Pharmacokinetic Research, School of Health Sciences, University of Manchester, Manchester, United Kingdom. Electronic address:

Several clinical studies have shown that COVID-19 increases the systemic concentration of drugs in hospitalized patients with COVID-19. However, it is unclear how COVID-19-mediated bidirectional dysregulation of hepatic and pulmonary cytochrome P450 (CYP) 3A4 affects drug concentrations, especially in the lung tissue, which is most affected by the disease. Herein, physiologically based pharmacokinetic modeling was used to demonstrate the differences in systemic and pulmonary concentrations of 4 respiratory infectious disease drugs when CYP3A4 is concurrently downregulated in the liver and upregulated in the lung based on existing clinical data on COVID-19-CYP3A4 interactions at varying severity levels including outpatients, non-intensive care unit (ICU), and ICU patients.

View Article and Find Full Text PDF

Universal cytomegalovirus (CMV) prophylaxis is recommended for at-risk lung transplant recipients. Valganciclovir is currently the preferred first-line agent. Valganciclovir-related myelosuppression, however, can lead to drug discontinuation or reduction in anti-metabolite immunosuppression.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!