AI Article Synopsis
- Chromatographic NMR uses stationary phases or solvent additives to enhance the diffusion behavior of analyte molecules, improving the resolution of measurements.
- The paper explores the effects of size exclusion chromatography on the diffusion coefficients of analyte molecules, using polymer standards of varying molecular weights.
- The findings are analyzed with a straightforward explanation of the size exclusion effect, shedding light on how molecular size impacts diffusion.
Article Abstract
Chromatographic NMR describes the use of stationary phases or solvent additives, such as polymers, to modify the diffusion properties of analyte molecules and thereby improve the observed resolution in the diffusion domain. This paper demonstrates similar ideas using size exclusion chromatographic media and characterises the changes in the observed diffusion coefficient using a series of polymer molecular weight reference standards of known polydispersity. The results are interpreted in terms of a simple description of the size exclusion phenomena.
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| http://dx.doi.org/10.1016/j.jmr.2012.04.017 | DOI Listing |
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