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Background: The healing response to cardiac implantable electronic device (CIED) implantation results in inflammation that can lead to fibrous pocket formation, which may disrupt pocket healing or complicate future interventions.
Objective: The purpose of this study was to assess CIED pocket healing with use of the second-generation TYRX absorbable antibacterial envelope (T2), the next-generation (NG) TYRX absorbable antibacterial envelope under development, and the CanGaroo® extracellular matrix envelope (ECM) compared to no envelope.
Methods: A total of 110 CIEDs were implanted in an ovine model, either with (T2, NG, or ECM) or without envelopes.
Monolithic silicon for high spatiotemporal translational photostimulation.
Nature
February 2024
The James Franck Institute, The University of Chicago, Chicago, IL, USA.
Electrode-based electrical stimulation underpins several clinical bioelectronic devices, including deep-brain stimulators and cardiac pacemakers. However, leadless multisite stimulation is constrained by the technical difficulties and spatial-access limitations of electrode arrays. Optogenetics offers optically controlled random access with high spatiotemporal capabilities, but clinical translation poses challenges.
View Article and Find Full Text PDFGene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy.
Cell Stem Cell
April 2023
Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Brotman Building Room 453, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA 98195, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195, USA; Sana Biotechnology, Seattle, WA 98102, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. Electronic address:
Article Synopsis
- Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show potential as a treatment for heart attacks, but they often cause temporary irregular heartbeats known as engraftment arrhythmias (EAs).
- Researchers believe these EAs are due to the immature nature of hPSC-CMs, as they exhibit pacemaker-like activity influenced by specific ion channels.
- By modifying the ion channels in these stem cells to reduce automaticity, the study demonstrated that these engineered cells can be safely transplanted into pig hearts without causing sustained EAs, supporting the idea that improving the electrophysiological properties of hPSC-CMs could enhance their use in heart therapies.
An Incidental Finding of Congenital Complete Heart Block Presenting in Active Labor: A Multidisciplinary Approach.
Cureus
March 2022
Obstetrics and Gynaecology, Jorhat Christian Medical Centre, Jorhat, IND.
Congenital complete heart block is a rare occurrence. In some cases, it remains asymptomatic until adulthood or in the case of women until pregnancy. It is usually secondary to placental transfer of maternal antibodies and is associated with high mortality and morbidity.
View Article and Find Full Text PDFCircadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions.
Front Neurosci
March 2022
School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, NSW, Australia.
Circadian rhythms are cyclic patterns of physiological, behavioural and molecular events that occur over a 24-h period. They are controlled by the suprachiasmatic nucleus (SCN), the brain's master pacemaker which governs peripheral clocks and melatonin release. While circadian systems are endogenous, there are external factors that synchronise the SCN to the ambient environment including light/dark cycles, fasting/fed state, temperature and physical activity.
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