AI Article Synopsis
- Curcumin is an herbal medicine used for treating conditions like inflammation and cancer, but its effectiveness is limited by poor absorption and lack of effective monitoring methods.
- A new liquid chromatography-tandem mass spectrometry method has been developed to simultaneously measure curcumin and its metabolite, curcumin-O-glucuronide (COG), in human plasma.
- This technique shows high accuracy and precision in quantifying these substances and successfully detected COG in plasma samples from individuals after consuming curcumin.
Article Abstract
Curcumin is a widely used herbal medicine for various human diseases including inflammation and cancer. The demonstration and optimization of curcumin's activities in the clinical setting, however, have been compromised by its poor bioavailability and the lack of analytic methods to monitor its absorption. In this paper, we report the first validated liquid chromatography-tandem mass spectrometric method for simultaneous quantification of curcumin and its major metabolite: curcumin-O-glucuronide (COG), in the linear range of 2.0-2000 ng/mL in human plasma. The intra-day and inter-day accuracies of curcumin and COG in human plasma were in the range of 91.3-111.5% and 82.7-109.2% and their co-efficiency of variations were in the range of 3.5-12.7% and 3.1-11.3%, respectively. This method was capable of detecting only COG in human plasma samples from two healthy volunteers after an oral ingestion of curcumin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387345 | PMC |
| http://dx.doi.org/10.1016/j.jchromb.2012.05.026 | DOI Listing |
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