Objectives: Exercise to failure results in similar muscle protein synthesis responses, independent of intensity. However, low-intensity exercise likely requires more time under tension and those with injuries may be incapable of sustaining the mechanical stress to reach failure.
Design: The purpose was to determine whether elastic knee wraps (KW) provide a stimulus to decrease time under tension and overall volume of work while maintaining a similar level of metabolic stress.
Methods: Thirteen healthy subjects participated in a randomized crossover study consisting of three trials. The first determined 1 repetition maximum (1RM) on the bilateral leg extension. Subjects were then assigned to a blood flow restriction (BFR) or control (CON) group. After trial 2, subjects crossed over to the opposite trial. KW were placed around the thigh of each leg during BFR. Leg extensions were completed at 30% 1RM until failure. Whole blood lactate (WBL) was taken pre-, post-, and 3 and 5 min postexercise. Heart rate (HR) was measured before, following the first and second sets, and 3 and 5 min postexercise.
Results: This study found KW provide a BFR stimulus allowing failure to occur sooner with similar metabolic stress postreperfusion. There were no differences in HR at any time point.
Conclusions: These results may benefit populations that cannot sustain the mechanical stress of high-intensity exercise or low-intensity exercise that requires a longer sustained time under tension.
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http://dx.doi.org/10.1111/j.1475-097X.2012.01121.x | DOI Listing |
Int J Gynaecol Obstet
January 2025
Department of Obstetrics and Gynecology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague 10, Czech Republic.
Negative pressure wound therapy (NPWT) is a very effective method in the treatment of dehiscent, infected, and non-healing wounds. Difficult wound healing occurs especially in late pregnancy due to the rapid enlargement of the uterus and the constantly increasing tension of the entire abdominal wall. In cases of dehiscence of the surgical wound during pregnancy, proper subsequent treatment is needed, where it is necessary to consider the safety of the mother as well as the fetus.
View Article and Find Full Text PDFAAPS J
January 2025
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Freeze drying is one of the common methods to extend the long-term stability of biologicals. Biological products in solid form have the advantages of convenient transportation and stable long-term storage. However, long reconstitution time and extensive visible bubbles are frequently generated during the reconstitution process for many freeze-dried protein formulations, which can potentially affect the management efficiency of staff, patient compliance, and product quality.
View Article and Find Full Text PDFClin Biomech (Bristol)
January 2025
Department of Mechanical Engineering, University of Michigan, 2350 Hayward St, Ann Arbor, MI 48109, United States; Department of Biomedical Engineering, University of Michigan, 200 Bonisteel Blvd, Ann Arbor, MI 48109, United States. Electronic address:
Background: The lower birth canal is the final constriction through which a fetal head must pass for delivery. Unfortunately, injuries to the lower birth canal tissues occur in up to 19 % of first-time vaginal deliveries due to the 300 % stretch required.
Methods: This is a secondary analysis of data from 56 healthy nullipara recorded by a lower birth canal dilator during the first stage of labor.
Plast Reconstr Surg Glob Open
January 2025
From the Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
Subcutaneous indwelling of nonabsorbable threads for tissue fixation and tension reduction is often used in plastic surgery and is applied in breast reduction surgery, umbilicoplasty, and in frontalis muscle lifting for congenital ptosis. However, in a few cases, exposure of the indwelling thread necessitates its removal. Exposure of the indwelling threads mostly occurs due to exposure of the knots.
View Article and Find Full Text PDFSoft Matter
January 2025
LENS (European Laboratory for Non-Linear Spectroscopy) Via Nello Carrara 1, 50019 Sesto Fiorentino (FI), Italy.
Liquid Crystalline Networks (LCNs) are widely investigated to develop actuators, from soft robots to artificial muscles. Indeed, they can produce forces and movements in response to a plethora of external stimuli, showing kinetics up to the millisecond time-scale. One of the most explored preparation technique involves the photopolymerization of an aligned layer of reactive mesogens.
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