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An unusual case of swelling--Clarkson's syndrome. | LitMetric

An unusual case of swelling--Clarkson's syndrome.

BMJ Case Rep

Department of Internal Medicine, Spectrum Health, Grand Rapids, Michigan, United States.

Published: August 2011

Clarkson's syndrome, also called idiopathic systemic capillary leak syndrome is a rare condition characterised by vascular hyper permeability resulting in extreme intravascular volume depletion. The syndrome is unique and almost paradoxical in its presentation, with findings initially suggesting overwhelming heart failure, but in reality the extra vascular fluid represents overt capillary leak, with ultimate intravascular volume depletion, a low output state and hypovolemic shock. Previously described characteristics have classically included severe oedema and anasarca with rapid, profound shock, typically accompanied by haemoconcentration. The authors describe a patient, initially seeming benign in presentation, who rapidly progressed with confusing findings of fluid overload by examination and imaging, ultimately manifesting these findings by severe capillary leak rather than hydrostatic oedema, with ultimate hypovolaemic shock, multisystem organ failure and death. Our aim is that by describing clinical, haemodynamic and pathologic descriptors of the disease, the authors can aid in increasing physician awareness of this unusual syndrome.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176369PMC
http://dx.doi.org/10.1136/bcr.06.2011.4405DOI Listing

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