A series of η(4)-acyloxycyclohexadiene-Fe(CO)(3) complexes was prepared and fully characterized by spectroscopic methods including single crystal X-ray diffraction. For this purpose a new synthetic access to differently acylated 1,3- and 1,5-dienol-Fe(CO)(3) complexes was developed. The enzymatically triggered CO release from these compounds was monitored (detection of CO through GC and/or by means of a myoglobin assay) and the anti-inflammatory effect of the compounds was assessed by a cellular assay based on the inhibition of NO-production by inducible NO synthase (iNOS). It was demonstrated that the properties (rate of esterase-triggered CO release, iNOS inhibition, cytotoxicity) of the complexes strongly depend on the substitution pattern of the π-ligand and the nature of the acyloxy substituent.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2dt30662jDOI Listing

Publication Analysis

Top Keywords

acyloxybutadiene tricarbonyl
4
tricarbonyl iron
4
complexes
4
iron complexes
4
complexes enzyme-triggered
4
enzyme-triggered co-releasing
4
co-releasing molecules
4
molecules et-corms
4
et-corms structure-activity
4
structure-activity relationship
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!