Influenza A virus variants were found to be capable of inducing synthesis of avid antibodies when different species and lines of animals were immunized. CBA mice were the most convenient model permitting differentiation of "avidogenic" from "nonavidogenic" virus variants with a high degree of certainty. Recombinants may differ from parental viruses in their capacity to induce synthesis of avid antibody; with this, the transmission of only one gene (HA) from the "avidogenic" parent into the system of genes of A/PR/8/34 st in ensured a high "avidogenicity" of the recombinant. The "avidogenic" virus variants had a more marked protective effect than "nonavidogenic" ones.
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Alzheimers Res Ther
December 2024
Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Background: Among the Alzheimer's disease (AD) biomarkers measured in blood, phosphorylated forms of tau (p-tau) have been shown to exhibit a particularly high diagnostic potential. Here, we performed a comprehensive method comparison study, followed by evaluation of the diagnostic performance of eight recent plasma p-tau immunoassays targeting different tau phosphorylation sites, different tau fragments, and that are measured by two distinct platforms.
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Radiol Case Rep
February 2025
Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610000, China.
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Hum Brain Mapp
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Department of Neuroscience, UC Berkeley, Berkeley, California, USA.
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