[Experience in the use of extracorporeal correction of the immune system in the treatment of patients with LOR cancer].

Correction of the immune status is one of the burning problems of current otorhinolaryngology. Recent developments in immunology allow interference at the cellular level. However, otorhinolaryngological practice is still based on oral, parenteral or local use of ineffective drugs. This paper presents early results of the application of extracorporeal cytapheresis combined with the modulator treatment of lymphocytes for the surgical therapy of 25 patient with ENT malignant neoformations of different stage and localization. Leukocytapheresis, i. e. separation of leukocytes, was performed by means of an Aminco (USA) or FK-3,5 (USSR) cell separator and the separated cells were treated with diuciphone. This method yielded good results as suggested by immunological, immunochemical, biophysical, and cytological measurements of blood. The method seems promising for ENT-cancer therapy.