Ischemic stroke is arguably the most feared complication of atrial fibrillation. While warfarin has been the most effective pharmacologic treatment for stroke prevention in patients with nonvalvular atrial fibrillation, several limitations have led to its underutilization. Recently, dabigatran (Pradaxa), a new oral anticoagulant with several potential advantages over warfarin (Coumadin), became available for use in the United States for prevention of stroke and systemic embolism in patient with nonvalvular atrial fibrillation.
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Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
From 1999 to 2020, age-adjusted mortality rates (AAMR) for atrial fibrillation-related deaths among U.S. adults (age ≥25) with comorbid diabetes mellitus increased significantly with an annual percent change of 6.
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Department of Cardiology, the First Affiliated Hospital of Dalian Medical University.
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