AI Article Synopsis
- A study tested the effectiveness and safety of 5 mg allicin adhesive tablets for treating minor recurrent aphthous ulcers.
- Researchers conducted a double-blinded, placebo-controlled trial where participants received either allicin or a placebo four times a day for five days.
- The results showed that allicin significantly reduced both the size and pain of ulcers without any major side effects, suggesting it is a beneficial treatment option.
Article Abstract
Objective: We investigated the effectiveness and safety of topical application of 5 mg allicin adhesive tablets in the treatment of minor recurrent aphthous ulcerations (MiRAU).
Material And Methods: A randomized, double-blinded, placebo-controlled, clinical trial was performed. Tablets containing 5 mg allicin or vehicle only were consecutively applied 4 times per day for 5 days. The size and pain level of ulcers were measured and recorded on days 1, 2, 4, and 6.
Results: A total of 96 subjects with MiRAU fulfilled the study. Allicin adhesive tablets significantly reduced ulcer size (P < .005, P < .003, P < .001 for days 2, 4, and 6, respectively) and alleviated ulcer pain score (P < .03, P < .001, P < .05 for days 2, 4, and 6, respectively) compared with vehicle tablets. Minor and major adverse reactions were not observed.
Conclusions: Allicin adhesive tablets were effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of MiRAU without significant side effects.
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| http://dx.doi.org/10.1016/j.oooo.2011.09.007 | DOI Listing |
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