Conclusion: The results of this study demonstrate that a conversion from the Duet to Duet 2 audio processor greatly improved patient satisfaction and subjective benefits.
Objectives: The aims of this study were to compare the DUET 2 audio processor to the DUET speech processor and to evaluate DUET 2 user satisfaction subjectively.
Methods: Ten experienced electric acoustic stimulation (EAS) users following partial deafness treatment upgraded from the MED-EL DUET to the DUET 2 were tested with the adaptive auditory speech test, Pruszewicz monosyllabic word test, visual analog scales, and Duet 2 user questionnaire. Tests were performed post-upgrade and compared simultaneously to the DUET at three test intervals over 3 months.
Results: Objective analyses showed that all subjects performed as well with the DUET 2 as the DUET. There was a tendency toward better results with the DUET 2. Subjective testing indicated DUET 2 user preference upon speech and musical stimuli. DUET 2 subject satisfaction was high for wearing comfort, sound quality, and for FineTuner and Private Alert features.
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http://dx.doi.org/10.3109/00016489.2012.654852 | DOI Listing |
J Voice
December 2024
SLT Department, Uskudar University, Istanbul, Turkey. Electronic address:
Objective: The purpose of this study is to examine the effects of a short-term (30 minutes) vocal loading task (VLT) on the objective and subjective parameters of voice and determine the restorative strategies of three different vocal exercises performed after the VLT.
Methods: The sample of the study included 30 normophonic women. The protocols that were applied in the study were carried out on three consecutive days.
mBio
December 2024
Department of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan, USA.
Unlabelled: The nickel-pincer nucleotide (NPN) cofactor is a modified pyridinium mononucleotide that tri-coordinates nickel and is crucial for the activity of certain racemases and epimerases. LarB, LarC, and LarE are responsible for NPN synthesis, with the cofactor subsequently installed into LarA homologs. Hurdles for investigating the functional properties of such proteins arise from the difficulty of obtaining the active, NPN cofactor-loaded enzymes and in assaying their diverse reactivities.
View Article and Find Full Text PDFRNA Biol
December 2025
Biochemistry and Biophysics Department, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
More than 4,000 single nucleotide polymorphisms (SNP) variants have been identified in the human gene, however only a few have been studied in the context of protein function. The tandem zinc finger domain of ZFP36L2, an RNA binding protein, is the functional domain that binds to its target mRNAs. This protein/RNA interaction triggers mRNA degradation, controlling gene expression.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-Do 24252, Republic of Korea.
The research aims to identify and characterize the antibody escape mutations of NTD and RBD regions of SARS-CoV-2 using prompt engineering-enabled combined LLMs (large language models) and instigative bioinformatics techniques. We used two LLMs (ChatGPT and Mistral 7B) and one MLLM (Gemini model) to retrieve the significant NTD and RBD mutations. The retrieved significant mutations were characterized through the in silico servers.
View Article and Find Full Text PDFiScience
December 2024
Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therapy induced senescent cells that resist these drugs by relying upon the anti-apoptotic and metabolic effects of activated STAT3. Furthermore, these senescent cells expand the repertoire of cells resistant to these drugs by secreting an array of factors, including TGFβ, which induce proliferating cells to exit mitosis and become quiescent-a state that also resists spindle inhibitors.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!