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Toxicity assessment and bioimaging potential of carbon dots synthesized from banana peel in zebrafish model.
Narra J
December 2024
Research Group of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Bandung, Indonesia.
Zebrafish serve as a pivotal model for bioimaging and toxicity assessments; however, the toxicity of banana peel-derived carbon dots in zebrafish has not been previously reported. The aim of this study was to assess the toxicity of carbon dots derived from banana peel in zebrafish, focusing on two types prepared through hydrothermal and pyrolysis methods. Banana peels were synthesized using hydrothermal and pyrolysis techniques and then compared for characteristics, bioimaging ability, and toxicity in zebrafish as an animal model.
View Article and Find Full Text PDFChimpanzee Activity and Behavioral Diversity Extends Across 24 Hours in Both Captive and Wild Settings.
Am J Primatol
January 2025
Department of Anthropology, Washington University in Saint Louis, Saint Louis, Missouri, USA.
Studying nocturnal behavior is crucial for understanding the full scope of a species' behavioral flexibility so as to inform the conservation of wild populations and the care of captive individuals. However, this aspect of primate behavior is understudied, especially in great apes, which exhibit some of the widest documented behavioral diversity and flexibility. Our investigation is among the first to systematically compare the 24 h activity patterns and behavioral activities of captive chimpanzees (Saint Louis Zoo, USA) with those of wild chimpanzees (three sites across the Nouabalé-Ndoki National Park in the Republic of Congo) and a published data set of the nocturnal behavior of all chimpanzee subspecies.
View Article and Find Full Text PDFChallenges and opportunities for validation of AI-based new approach methods.
ALTEX
January 2025
National Institutes of Health, National Institute for Environmental Health Sciences, DTT/NICEATM, Durham, NC, USA.
The integration of artificial intelligence (AI) into new approach methods (NAMs) for toxicology rep-resents a paradigm shift in chemical safety assessment. Harnessing AI appropriately has enormous potential to streamline validation efforts. This review explores the challenges, opportunities, and future directions for validating AI-based NAMs, highlighting their transformative potential while acknowledging the complexities involved in their implementation and acceptance.
View Article and Find Full Text PDFAcquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos.
Epigenetics Chromatin
January 2025
Department of Maternal‑Fetal Biology, National Center for Child Health and Development, Tokyo, 157‑8535, Japan.
Background: DNA methylation plays a crucial role in mammalian development. While methylome changes acquired in the parental genomes are believed to be erased by epigenetic reprogramming, accumulating evidence suggests that methylome changes in sperm caused by environmental factors are involved in the disease phenotypes of the offspring. These findings imply that acquired sperm methylome changes are transferred to the embryo after epigenetic reprogramming.
View Article and Find Full Text PDFLarviciding for malaria control and elimination in Africa.
Malar J
January 2025
RBM Partnership Vector Control Working Group, Chem du Pommier 40, 1218, Le Grand-Saconnex, Switzerland.
Background: Global progress toward malaria elimination and eradication goals has stagnated in recent years, with many African countries reporting increases in malaria morbidity and mortality. Insecticide-treated nets and indoor residual spraying are effective, but the emergence and increased intensity of insecticide resistance and the challenge of outdoor transmission are undermining their impact. New tools are needed to get back on track towards global targets.
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