AI Article Synopsis
- The study focused on the treatment of parotid gland cancers using stereotactic body radiosurgery (SBRT) at a single institution between 2003 and 2011.
- A total of 13 patients received SBRT with a median dose of 33 Gy; most were older males, and many chose this treatment over conventional radiation due to prior therapies or personal preference.
- Follow-up results showed that one patient had local failure and four experienced distant failures, with overall survival rates at two years being 46%, and the study suggested that surgery improved survival outcomes.
Article Abstract
Background: to review a single-institution experience with the management of parotid malignancies treated by fractionated stereotactic body radiosurgery (SBRT).
Findings: Between 2003 and 2011, 13 patients diagnosed with parotid malignancies were treated with adjuvant or definitive SBRT to a median dose of 33 Gy (range 25-40 Gy). There were 11 male and two female patients with a median age of 80. Ten patients declined conventional radiation treatment and three patients had received prior unrelated radiation therapy to neighboring structures with unavailable radiation records. Six patients were treated with definitive intent while seven patients were treated adjuvantly for adverse surgical or pathologic features. Five patients had clinical or pathologic evidence of lymph node disease.
Conclusion: at a median follow-up of 14 months only one patient failed locally, and four failed distantly. The actuarial 2-year overall survival, progression-free survival, and local-regional control rates were 46, 84, and 47%, respectively. Statistical analysis revealed surgery as a positive predictor of overall survival while presence of gross disease was a negatively correlated factor (p < 0.05).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364484 | PMC |
| http://dx.doi.org/10.3389/fonc.2012.00055 | DOI Listing |
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