Objective: The aim of this study was to verify the possibility of lactate minimum (LM) determination during a walking test and the validity of such LM protocol on predicting the maximal lactate steady-state (MLSS) intensity.
Design: Eleven healthy subjects (24.2 ± 4.5 yr; 74.3 ± 7.7 kg; 176.9 ± 4.1 cm) performed LM tests on a treadmill, consisting of walking at 5.5 km · h⁻¹ and with 20-22% of inclination until voluntary exhaustion to induce metabolic acidosis. After 7 minutes of recovery the participants performed an incremental test starting at 7% incline with increments of 2% at each 3 minutes until exhaustion. A polynomial modeling approach (LMp) and a visual inspection (LMv) were used to identify the LM as the exercise intensity associated to the lowest [bLac] during the test. Participants also underwent to 2-4 constant intensity tests of 30 minutes to determine the MLSS intensity.
Results: There were no differences among LMv (12.6 ± 1.7%), LMp (13.1 ± 1.5%), and MLSS (13.6 ± 2.1%) and the Bland and Altman plots evidenced acceptable agreement between them.
Conclusion: It was possible to identify the LM during walking tests with intensity imposed by treadmill inclination, and it seemed to be valid on identifying the exercise intensity associated to the MLSS.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361292 | PMC |
http://dx.doi.org/10.1100/2012/769431 | DOI Listing |
PLoS One
January 2025
Department of Neuroscience, Laboratory of Prion Neurobiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays cerebellar Purkinje cell (PC) degeneration and the onset of ataxia in the woozy mouse model of MSS. However, GSK2606414 is toxic to the pancreas and does not completely rescue the woozy phenotype.
View Article and Find Full Text PDFAIMS Public Health
December 2024
Division of Otolaryngology - Head & Neck Surgery, Cooper University Health Care, Camden, NJ, USA.
Background: Underinsured patients with advanced head and neck cancer experience worse outcomes compared to their well-insured peers.
Methods: Retrospective logistic regression analysis testing associations between demographic, geospatial, transportation, disease, and treatment factors in 50 government insured or uninsured patients receiving curative-intent, multidisciplinary cancer care.
Results: Forty percent of patients missed at least one treatment or surveillance appointment within the first year.
J Orthop Case Rep
January 2025
Department of Orthopaedics, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Introduction: Ankylosing spondylitis (AS) is a chronic inflammatory disorder that primarily affects the spine and sacroiliac joints, leading to pain, stiffness, and progressive thoracolumbar kyphotic deformity. A key complication in advanced AS is the development of Andersson lesions (AL), degenerative vertebral lesions resulting from the disease's progression. These lesions can cause significant mechanical pain, often mistaken for the chronic discomfort associated with AS.
View Article and Find Full Text PDFBMC Geriatr
January 2025
School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Background: The global aging population has increased dynapenia prevalence, leading to mobility issues and poor sleep quality among older adults. Despite its impact, research on sleep quality in dynapenic outpatients is limited. This study investigates how physiological status, community participation, and daily activity function influence sleep quality in this group.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
Biomedical Engineering, Bahçeşehir University, Çırağan Caddesi Osmanpaşa Mektebi Sokak No: 4-6 Beşiktaş, İstanbul, 34353, Turkey.
This study aims to understand the impact of backpack carriage, a regular activity for many, on back muscles and joint mobility during walking so that clinicians can develop strategies or products to ensure individuals' safety and well-being. Surface electromyography (EMG) and XSENS Awinda motion capture systems were used to analyze the effects of carrying a backpack (12% of body weight) on erector spinae and multifidus muscles, as well as spinal, hip, knee, and ankle joints. Subjects walked at 4 km/h on flat and inclined surfaces.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!