Recurrent miscarriage is often unexplained. In our study, we test the hypothesis that unexplained recurrent miscarriage is associated with premature ovarian ageing by comparing the basal follicle-stimulating hormone (FSH) level between women with recurrent miscarriage and a control group of subjects in two different ethnic centres: one in Guangzhou, China and the other in Sheffield, UK. The subjects were stratified into three different age groups, and all of them were under the age of 40 years. We found no significant difference in basal FSH level between the subjects and the control groups, and the proportion of women with high FSH (>10 IU/l) was higher in the Guangzhou cohort but not in the Sheffield cohort. Our observation suggests that premature ovarian ageing is not a significant contributory factor of recurrent miscarriage, but a study on the ethnic variation in the aetiology of recurrent miscarriage is needed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/01443615.2012.668578 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intradermal lymphocyte therapy: A promising treatment for recurrent pregnancy loss in patients without anti-TPO antibodies.
Hum Immunol
January 2025
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
Background: Recurrent pregnancy loss (RPL) remains a complex and challenging reproductive issue often associated with immunological abnormalities. This study investigates the immunomodulatory effects of intradermal lymphocyte therapy in RPL patients, exploring cellular, molecular, and cytokine changes, with specific attention to individuals with positive anti-thyroid peroxidase antibodies (Anti-TPO).
Methods: The study included 105 patients with RPL, divided into Anti-TPO positive RPL patients (n = 25), Anti-TPO negative RPL patients (n = 38), and RPL patients without lymphocyte immunotherapy (LIT) (n = 42).
Unveiling the molecular mechanisms of recurrent miscarriage through endoplasmic reticulum stress related gene expression.
Sci Rep
January 2025
Department of TCM, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, China.
Recurrent miscarriage (RM) is a reproductive disorder affecting couples worldwide. The underlying molecular mechanisms remain elusive, even though emerging evidence has implicated endoplasmic reticulum stress (ERS). We investigated RM- and ERS-related genes to develop a diagnostic model that can enhance predictive ability.
View Article and Find Full Text PDFFertility journey of a patient with McCune-Albright syndrome associated with bilateral ovarian involvement.
F S Rep
December 2024
Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa, Ontario, Canada.
Objective: To report a patient with McCune-Albright syndrome (MAS) with bilateral ovarian involvement who had achieved a pregnancy through in vitro fertilization (IVF).
Design: Case report.
Setting: Academic fertility center.
Cervical length of preoperative cervical cerclage prognostic impacted the effect of cervical insufficiency.
BMC Pregnancy Childbirth
January 2025
Department of Gynecology, Jiangnan University Medical Center, 68 Zhongshan Road, Liangxi Strict, Wuxi, Jiangsu, 214002, China.
Background: This study aimed to analyze the impact of preoperative cervical length before cervical cerclage on the extension of gestational days in patients with various diagnostic types of cervical insufficiency, including obstetric history-based diagnosis, ultrasound-based diagnosis, and physical examination-based diagnosis.
Methods: 168 patients were segregated into four categories based on cervical length: 0-0.4 cm, 0.
Efficacy of Corticosteroids in Patients With Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis.
Am J Reprod Immunol
January 2025
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Recurrent pregnancy loss (RPL) represents a complication of pregnancy occurring in 1%-3% of all couples trying to conceive. About 50%-60% of RPL cases remain idiopathic, therefore therapeutic strategies seem empirical and based on unproven evidence. We investigated the efficacy of corticosteroids in women with RPL.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!