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Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake.
J Xenobiot
December 2024
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Addressing the consequences of exposure to endocrine-disrupting chemicals (EDCs) demands thorough research and elucidation of the mechanism by which EDCs negatively impact women and lead to breast cancer (BC). Endocrine disruptors can affect major pathways through various means, including histone modifications, the erroneous expression of microRNA (miRNA), DNA methylation, and epigenetic modifications. However, it is still uncertain if the epigenetic modifications triggered by EDCs can help predict negative outcomes.
View Article and Find Full Text PDFThe cation/H exchanger OsCAX2 is involved in cadmium uptake and contributes to differential grain cadmium accumulation between Indica and Japonica rice.
J Hazard Mater
January 2025
State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China; Sanya Institute of Nanjing Agricultural University, Sanya 572024, China. Electronic address:
Rice is a major source of dietary cadmium (Cd), a toxic heavy metal that poses serious threat to human health. How rice takes up and accumulates Cd is not fully understood. Here, we characterize the function of a cation/H exchanger, OsCAX2, in Cd uptake in roots and Cd accumulation in shoots and grains.
View Article and Find Full Text PDFCausal inference of whole-grain foods' risk based on a generative adversarial network and Bayesian network.
J Food Sci
January 2025
School of Computer and Artificial Intelligence, Beijing Technology and Business University, Beijing, China.
Whole-grain foods (WGFs) constitute a large part of humans' daily diet, making risk identification of WGFs important for health and safety. However, existing research on WGFs has paid more attention to revealing the effects of a single hazardous substance or various hazardous substances on food safety, neglecting the mutual influence between individual hazardous substances and between hazardous substances and basic information. Therefore, this paper proposes a causal inference of WGFs' risk based on a generative adversarial network (GAN) and Bayesian network (BN) to explore the mutual influence between hazardous substances and basic information.
View Article and Find Full Text PDFProbabilistic assessment of the cumulative risk from dietary heavy metal exposure in Chongqing, China using a hazard-driven approach.
Sci Rep
January 2025
School of Public Health, Chongqing Medical University, Chongqing, China.
Cumulative risk assessment is significant for evaluating the combined exposure to multiple substances, but its widespread acceptance and application have been limited due to the complexity of clarifying and assessing actual exposure. In this study, we conducted a cumulative risk assessment based on hazard-driven criteria to evaluate the co-exposure to elemental contaminants in the diet of the population in Chongqing Municipality. The cumulative risk was calculated and evaluated using Monte Carlo modeling and the modified Reference Point Index (mRPI) method.
View Article and Find Full Text PDFExploring pathological targets and advancing pharmacotherapy in autism spectrum disorder: Contributions of glial cells and heavy metals.
Histol Histopathol
January 2025
Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India.
Autism spectrum disorder (ASD) is a globally recognized neurodevelopmental condition characterized by repetitive and restrictive behavior, persistent deficits in social interaction and communication, mental disturbances, etc., affecting approximately 1 in 100 children worldwide. A combination of genetic and environmental factors is involved in the etiopathogenesis of the disease, but specific biomarkers have not yet been identified.
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