AI Article Synopsis
- Recent research suggests that group II metabotropic glutamate receptors (mGluR(2/3)) might play a role in the reinforcing effects of drugs like methamphetamine and could be targeted for addiction treatment.
- This study tested the effects of the mGluR(2/3) agonist LY379268 on rats that had different experiences with methamphetamine self-administration, comparing those with short access (ShA) versus long access (LgA) to the drug.
- Results showed that while both groups reinstated drug-seeking behaviors similarly under vehicle conditions, LgA rats were more sensitive to mGluR(2/3) stimulation, indicating that history of drug intake influences how these receptors affect
Article Abstract
Recent findings implicate group II metabotropic glutamate receptors (mGluR(2/3)) in the reinforcing effects of psychostimulants and have identified these receptors as potential treatment targets for drug addiction. Here, we investigated the effects of mGluR(2/3) stimulation on cue- and drug-primed reinstatement in rats with different histories of methamphetamine (METH) self-administration training, under two conditions: 16 daily sessions of short access (90 min/day, ShA), or 8 daily sessions of short access followed by 8 sessions of long access (6 h/day, LgA). Following self-administration and subsequent extinction training, rats were pretreated with the selective mGluR(2/3) agonist LY379268 (variable dose, 0-3 mg/kg), exposed to METH-paired cues or a priming injection of METH (1 mg/kg), and tested for reinstatement of METH-seeking behavior. LgA rats self-administered greater amounts of METH during the second half of training, but when pretreated with vehicle, ShA and LgA rats showed cue- and drug-primed reinstatement at equivalent response rates. However, LgA rats demonstrated greater sensitivity to mGluR(2/3) stimulation with attenuated responding during cue-induced reinstatement after 0.3 mg/kg and higher doses of LY379268, whereas ShA rats decreased cue-induced reinstatement behavior following 1.0 mg/kg and 3.0 mg/kg LY379268. Additionally, both LgA and ShA rats exhibited decreased METH-primed reinstatement behavior following 0.3 mg/kg and higher doses of LY379268. A separate group of control rats was trained to self-administer sucrose pellets, and demonstrated attenuated cue-induced sucrose-seeking behavior following 1.0 and 3.0 mg/kg LY379268. Together, the results indicate that LY379268 has differential attenuating effects on cue-induced reinstatement behavior in rats with different histories of METH intake. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442155 | PMC |
| http://dx.doi.org/10.1016/j.neuropharm.2012.05.037 | DOI Listing |
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