Introduction: Renal transplantation is an attractive alternative to haemodialysis for patients with renal failure. Preserving renal function after renal transplantation depends on rejection episodes and infections of the graft.
Purpose: To clarify the characteristics of acute pyelonephritis encountered in a population of kidney transplant patients and to discern risk factors occurring during the first year after transplantation.
Method: Data for all renal transplantations between January 1, 2006, and December 31, 2007 came from a database. Patients were at least 18 years old. A retrospective analysis was done.
Results: One hundred and eighty-four patients were included in the study. The incidence of acute pyelonephritis was 10.9%. In our sample, there were significantly more women who experienced pyelonephritis (P=0.012). Patients who had grafts with at least one episode of acute pyelonephritis were significantly younger (P=0.013) than transplanted patients without a history of acute pyelonephritis (44.4±10.5 and 52.2±13.4 years, respectively).
Conclusion: Our study shows a lower incidence of pyelonephritis compared with the literature. Moreover, we found that young age and female gender were risk factors for developing this infection.
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http://dx.doi.org/10.1016/j.purol.2012.01.012 | DOI Listing |
Antimicrob Steward Healthc Epidemiol
July 2024
Cardinal Health Innovative Delivery Solutions, Stafford, TX, USA.
Objective: The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.
Design: Institutional Review Board (IRB)-approved, multicenter, retrospective, non-inferiority cohort (15% non-inferiority margin).
Setting: Six hospitals within two healthcare systems.
J Comp Eff Res
January 2025
Advanz Pharma, London, UK.
Compared with uncomplicated urinary tract infections (UTIs), complicated UTIs (cUTIs) including acute pyelonephritis (AP) present with significant morbidity, a higher risk of treatment failure and typically require longer courses of treatment, or alternative antibiotics. The emergence of drug-resistant organisms represents a considerable challenge in the treatment of patients with cUTIs/AP and has limited antibiotic options. Carbapenems are considered the current last line of therapy, however, carbapenem resistance represents a growing problem.
View Article and Find Full Text PDFAccess Microbiol
January 2025
Department of Bacteriology, Mohammed V Military Teaching Hospital/Faculty of Medicine and Pharmacy (University Mohammed V), Rabat, Morocco.
Bacterial urinary tract infections (UTIs) are common, ranging from benign cystitis to complicated pyelonephritis, which can lead to severe complications such as pyonephrosis and sepsis. Pyonephrosis, characterized by the presence of pus in the renal cavities, often requires urgent urological intervention. We report a unique case of pyonephrosis with a psoas abscess caused by and in a 64-year-old diabetic female patient.
View Article and Find Full Text PDFJ Clin Pharmacol
January 2025
Department of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
This study evaluates the impact of acute pyelonephritis in pregnant women on the in vivo activity of renal OAT3 using the endogenous biomarker (EB) 6β-hydroxycortisol (6β-OHF) renal clearance (CL 6β-OHF) and AUC validated by correlating with the secretion clearance (CL) of the probe drug furosemide. Additionally, 6β-OHF formation clearance (CL 6β-OHF) as well as urinary (Ae/Ae) and plasma (AUC/AUC) ratios were also evaluated as EB for hepatic CYP3A activity. Pregnant women in their third trimester of gestation, diagnosed with acute pyelonephritis, were recruited before (pre-treatment, n = 8) and after (post-treatment, n = 8) cefuroxime treatment and resolution of acute pyelonephritis.
View Article and Find Full Text PDFCureus
December 2024
Emergency Medicine, Nagasaki Harbor Medical Center, Nagasaki, JPN.
, a rare human pathogen, has limited clinical data. This case report presents a case of sepsis, pyelonephritis, and septic spondylitis treated successfully with ampicillin. An 82-year-old woman was hospitalized for acute pyelonephritis and sepsis, presenting with fever and abdominal pain.
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