Widespread application of pancreas transplantation in diabetic patients without secondary complications or without a demonstrated propensity to develop complications will not be possible until antirejection strategies with fewer side effects have been developed. For now, pancreas transplants are restricted to patients whose complications of diabetes are more serious than those associated with chronic immunosuppression and the drugs necessary to prevent rejection. In these individuals, however, pancreas transplantation should be considered an established therapeutic procedure.
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