Interferon gamma-induced protein-10 is a diagnostic test for tuberculosis infection. There is no information on its concentrations over time. Interferon gamma-induced protein-10 was evaluated in 72 children formerly treated or in former contact with tuberculosis using Quantiferon Gold in-tube. Cases and contacts had similar interferon gamma-induced protein-10 concentrations. Concentrations varied with the tuberculin and interferon gamma release tests' concordance or discordance, and were independent of time.
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http://dx.doi.org/10.1097/INF.0b013e3182611152 | DOI Listing |
J Nutr
December 2024
Department of Nutrition, University of California, Davis, Davis, CA, United States; USDA Western Human Nutrition Research Center, University of California, Davis, Davis, CA, United States. Electronic address:
Background: Immune function is affected by vitamin D status but the optimal serum 25-hydroxy vitamin D [25(OH)D] level for immune function is not known.
Objectives: We hypothesized that 25(OH)D would be associated with markers of inflammation and immune activation.
Methods: We identified associations between 25(OH)D and immune markers from 361 healthy adults using polynomial regression.
Int J Cancer
December 2024
Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Immune checkpoint inhibitors (ICIs) targeting programmed death ligand-1 (PD-L1) provide clinical benefits for various advanced malignancies. However, the predictive factors that determine sensitivity to ICIs have not been fully elucidated. We focused on tumor-derived CXCL10/11 as a pivotal factor that determines the response to PD-L1 blockade by regulating T cell accumulation and tumor angiogenesis.
View Article and Find Full Text PDFJ Hepatocell Carcinoma
December 2024
The First Clinical Medical College of Jinan University, Guangzhou, 510000, People's Republic of China.
Purpose: Oxymatrine has potent anti-cancer activity, but its exact mechanism in liver cancer remains elusive. The present study was designated to explore oxymatrine's effect and the potential mechanism on Programmed cell death-ligand 1 (PD-L1) expression and ferroptosis in liver cancer.
Methods: Oxymatrine's influence on PD-L1 expression and ferroptosis-related proteins in liver cancer cells was explored in vitro and in vivo utilizing Western blotting, qRT-PCR, immunofluorescence, ELISA, H&E staining, immunohistochemistry, as well as detection of Fe, ROS, and MDA.
J Inflamm Res
November 2024
The First Department of Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People's Republic of China.
Background: Members of the interferon regulatory factor (IRF) family are transcriptional regulators that play vital roles in the inflammatory response of macrophages. IRF1, IRF3, and IRF9 regulate the expression of immune-responsive gene 1 (IRG1) in macrophages. However, the role of IRF2 in the inflammatory response of macrophages remains somewhat contradictory.
View Article and Find Full Text PDFMolecules
November 2024
Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Republic of Korea.
(Korean ginseng) is renowned for its health-promoting properties, attributed to its bioactive compounds, including saponins, polyphenols, and polysaccharides, which possess both antioxidant and anti-aging activities. This study investigated the anti-aging and anti-inflammatory effects of compounds isolated from the hot water extract of fresh roots, evaluating their resistance to TNF-α/IFN-γ-induced skin cell damage. Among 14 compounds, ginsenoside Rf (compound ) showed significant multi-target effects.
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