We have studied single-stranded DNA translocation through a semiconductor membrane consisting of doped p and n layers of Si forming a p-n-junction. Using Brownian dynamics simulations of the biomolecule in the self-consistent membrane-electrolyte potential obtained from the Poisson-Nernst-Planck model, we show that while polymer length is extended more than when its motion is constricted only by the physical confinement of the nanopore. The biomolecule elongation is particularly dramatic on the n-side of the membrane where the lateral membrane electric field restricts (focuses) the biomolecule motion more than on the p-side. The latter effect makes our membrane a solid-state analog of the α-hemolysin biochannel. The results indicate that the tunable local electric field inside the membrane can effectively control dynamics of a DNA in the channel to either momentarily trap, slow down or allow the biomolecule to translocate at will.
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http://dx.doi.org/10.1088/0957-4484/23/25/255501 | DOI Listing |
Nanoscale Horiz
January 2025
State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Bacterial infection in bone tissue engineering is a severe clinical issue. Traditional antimicrobial methods usually cause problems such as bacterial resistance and biosecurity. Employing semiconductor photocatalytic antibacterial materials is a more controlled and safer strategy, wherein semiconductor photocatalytic materials generate reactive oxygen species under illumination for killing bacteria by destroying their cell membranes, proteins, DNA, In this review, P-type and N-type semiconductor photocatalytic materials and their antibacterial mechanisms are introduced.
View Article and Find Full Text PDFMicrosyst Nanoeng
January 2025
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Nanoelectromechanical systems (NEMS) based on atomically-thin tungsten diselenide (WSe), benefiting from the excellent material properties and the mechanical degree of freedom, offer an ideal platform for studying and exploiting dynamic strain engineering and cross-scale vibration coupling in two-dimensional (2D) crystals. However, such opportunity has remained largely unexplored for WSe NEMS, impeding exploration of exquisite physical processes and realization of novel device functions. Here, we demonstrate dynamic coupling between atomic lattice vibration and nanomechanical resonances in few-layer WSe NEMS.
View Article and Find Full Text PDFAnal Chem
January 2025
Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, School of Food Sciences and Engineering, State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
This work utilized a combination of photocatalytic organic semiconductors and bacteria to create a photocatalytic organic semiconductor-bacterial biomixture system based on a bacteria imprinted polymers (OBBIPs-PEC) sensor, for the detection of with high sensitivity in "turn-on" mode at the single-cell level. This outstanding sensor arises from an integration of two different types of semiconductor materials to form heterojunctions. As well this sensor involves combining a semiconductor material with cationic side chains and an electron transport chain within a natural cellular environment, in which the cationic side chain of poly(fluorene--phenylene) organic semiconductor at 2-(4-mesyl-2-nitrobenzoyl)-1,3-cyclohexanedione (PFP-OC@MNC) demonstrated the ability to penetrate the cell membrane of and interact with specific binding sites through electrostatic interactions.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Soochow Institute for Energy and Materials Innovation, Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou, 215006, China.
The Zn metal anode in aqueous zinc-ion batteries (AZIBs) faces daunting challenges including undesired water-induced parasitic reactions and sluggish ion migration kinetics. Herein, we develop three-dimensional covalent organic framework (COF) membranes with bioinspired ion channels toward stabilized Zn anodes. These COFs, featured by zincophilic pyridine-N sites, enable effective regulation of water molecules at the anode-electrolyte interphase.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
Gasdermin (GSDM)-mediated pyroptosis involves the induction of mitochondrial damage and the subsequent release of mitochondrial DNA (mtDNA), which is anticipated to activate the cGAS-STING pathway, thereby augmenting the antitumor immune response. However, challenges lie in effectively triggering pyroptosis in cancer cells and subsequently enhancing the cGAS-STING activation with specificity. Herein, we developed intelligent self-cascaded pyroptosis-STING initiators of cobalt fluoride (CoF) nanocatalysts for catalytic metalloimmunotherapy.
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