Objective: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring.
Design: Analysis of data from a cohort study.
Setting: Academic hospital in Leiden, the Netherlands.
Participants: 133 cases and 164 control individuals, aged 18-20 years at follow-up.
Main Outcome Measure: Incidence of substance use disorder or use of alcohol and tobacco.
Results: The lifetime use of addictive substances in children exposed to intrapartum Pethidine analgesia was 45% of 133 children versus 48% of 164 not-exposed subjects (adjusted OR=0.79, 95% CI 0.48 to 1.29). Recent use of alcohol, tobacco and hard drugs showed no statistical difference either.
Conclusion: Pethidine for labour pain medication appears not to be associated with substance misuse or smoking in later life.
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| http://dx.doi.org/10.1136/bmjopen-2011-000719 | DOI Listing |
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