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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs.
Molecules
January 2025
MBC Pharma Inc., Aurora, CO 80045, USA.
Background: The use of the bone-seeking properties of bisphosphonates (BPs) to target the delivery of therapeutic drugs is a promising approach for the treatment of bone metastases. Currently, the most advanced example of this approach is a gemcitabine-ibandronate conjugate (GEM-IB), where the bone-targeting BP ibandronate (IB) is covalently linked to the antineoplastic agent gemcitabine (GEM) via a spacer phosphate group. In the present study, we describe the development of a new analytical platform to evaluate the metabolism and pharmacokinetics of GEM-IB in mice and dogs and the results of proof-of-concept studies assessing the pharmacokinetics of GEM-IB in dogs and mice.
View Article and Find Full Text PDFProficiency-chasing and goalodicy: In prioritising checklists, are we gambling with the future of mental health nursing?
Nurse Educ Today
January 2025
School of Nursing and Midwifery, University of Central Lancashire, United Kingdom of Great Britain and Northern Ireland. Electronic address:
In this discussion paper, I take a critical approach to the use of standardised checklists in practice assessment documents as a valid method of assessing mental health nursing students in the UK. The game Bingo is applied here as a metaphor, highlighting the folly of using standardised cross-field checklists to assess mental health nursing students in practice. Such practices, I argue, amount to little more than a game of proficiency-chasing at the expense of seeking more meaningful learning experiences, especially where practice assessment documents currently prioritise physical health care skills above those required for successful mental health nursing.
View Article and Find Full Text PDFEstimation of Diagnostic Test Accuracy Without Gold Standards.
Stat Med
February 2025
Department of Biostatistics and Beijing International Center for Mathematical Research, Peking University, Beijing, China.
The ideal evaluation of diagnostic test performance requires a reference test that is free of errors. However, for many diseases, obtaining such a "gold standard" reference is either impossible or prohibitively expensive. Estimating test accuracy in the absence of a gold standard is therefore a significant challenge.
View Article and Find Full Text PDFDevelopment and Validation of the Scale of Hypoglycemia Self-Care Behavior in Type 2 Diabetes.
Nurs Res
January 2025
Kaohsiung Medical University, College School of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung, Taiwan.
Background: Inappropriate dietary, exercise, and medication self-care behaviors among persons with diabetes can easily trigger hypoglycemia. Clinically, it is necessary to quickly identify high-risk groups for hypoglycemic events to provide targeted hypoglycemia education. However, there is currently a lack of precise tools to assess self-care behaviors related to hypoglycemia.
View Article and Find Full Text PDFValidation of a Questionnaire Assessing Pregnant Women's Perspectives on Addressing the Psychological Challenges of Childbirth.
Nurs Rep
December 2024
Department of Microbiology, Parasitology and Virology, Faculty of Midwives and Nursing, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Introduction: Pregnant women's experiences and concerns regarding childbirth are complex, necessitating a multidimensional and personalized approach in maternal care. This study explores the psychological and emotional factors influencing pregnant women's decisions regarding their mode of delivery. The results will provide valuable insights for the development of educational and counseling strategies designed to support pregnant women in making informed and conscious decisions about their childbirth.
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