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Investigation on the reversal effect of closantel on colistin resistance in MCR-1 positive Escherichia coli based on dose-response relationship.
J Antimicrob Chemother
December 2024
Department of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan 450046, China.
Article Synopsis
- This study explores how the deworming drug closantel (CST) can reverse colistin resistance in mcr-1-positive E. coli, filling a gap in research on dosage for adjuvants in clinical therapy.
- Utilizing various methods, the research demonstrates that CST has a unique dose-response relationship that is not reliant on higher concentrations for effectiveness.
- The findings suggest that CST not only prevents the development of colistin resistance but also shows promising therapeutic effects when combined with colistin in a mouse infection model.
Fosfatriclaben: Effective dose determination and comparative efficacy assessment with closantel, triclabendazole+ivermectin, triclabendazole+albendazole in artificially infected cattle.
Exp Parasitol
November 2024
Facultad de Medicina Veterinaria y Zootecnia, Departamento de Parasitología, Universidad Nacional Autónoma de México, CDMX, 04510, Mexico.
Two controlled efficacy studies were conducted to determine the effective dose of fosfatriclaben (FTCB) and compare its fasciolicidal efficacy with that of three commercial products against eggs and adult stages of Fasciola hepatica in artificially infected cattle. In study 1, 20 trematode-free Holstein Friesian steers were infected on day 0 with 500 F. hepatica metacercariae.
View Article and Find Full Text PDFRevisiting anthelmintic resistance in sheep flocks from São Paulo State, Brazil.
Int J Parasitol Drugs Drug Resist
April 2024
Southeast Livestock Unit, Brazilian Agricultural Research Corporation (EMBRAPA), São Carlos, SP, Brazil.
Haemonchus contortus and Trichostrongylus colubriformis are the most important gastrointestinal nematodes causing serious losses in sheep production of tropical and subtropical regions. Prophylaxis of gastrointestinal nematode infections is based on anthelmintics use, but their frequent administration selects multiple-resistant parasites. To evaluate how the situation has changed over the last decades, the anthelmintic resistance status of gastrointestinal nematodes in sheep flocks was assessed in the current study and compared to previous surveys.
View Article and Find Full Text PDFEfficacy of flukicides against Fasciola hepatica and first report of triclabendazole resistance on German sheep farms.
Int J Parasitol Drugs Drug Resist
December 2023
Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Robert-von-Ostertag-Str. 7, 14163, Berlin, Germany. Electronic address:
Fasciola hepatica infections lead to severe health problems and production losses in sheep farming, if not treated effectively. Triclabendazole has been used extensively over decades due to its unique efficacy range against all definitive hostfluke stages but published data about the susceptibility of F. hepatica to anthelmintics in Germany are lacking.
View Article and Find Full Text PDFTriclabendazole resistance in Fasciola hepatica: First report in sheep from the Santa Cruz province, Argentinian Patagonia.
Vet Parasitol Reg Stud Reports
October 2023
Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Facultad de Ciencias Veterinarias, Campus Universitario, Tandil, Buenos Aires, Argentina.
In the fall of 2022, decreased triclabendazole (TCBZ) efficacy against F. hepatica was suspected in a sheep farm located in the Santa Cruz province, Argentinian Patagonia. Since TCBZ-resistance in F.
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