Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/09537104.2012.682105 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tissue growth as a mechanism for collagen fiber alignment in articular cartilage.
Sci Rep
December 2024
Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Postbus 513, Eindhoven, 5600 MB, The Netherlands.
Articular cartilage is distinguished by the unique alignment of type II collagen, a feature crucial for its mechanical properties and function. This characteristic organization is established during postnatal development of the tissue, yet the underlying mechanisms remain poorly understood. In this study, a potential mechanism for type II collagen alignment by cartilage-specific growth from within the tissue was investigated.
View Article and Find Full Text PDFMolecular and biological characterization of transforming growth factor-β homolog derived from Trichinella spiralis.
Sci Rep
December 2024
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
The cytokine homologs, particularly transforming growth factor (TGF)-β, is a crucial immunomodulatory molecule and involved in growth and developmental processes in several helminths. In this study, the basic properties and functions of T. spiralis TGF-β homolog 2 (TsTGH2) were characterized using bioinformatics and molecular biology approaches.
View Article and Find Full Text PDFGene expression modulation in human aortic smooth muscle cells under induced physiological mechanical stretch.
Sci Rep
December 2024
Mines Saint-Etienne, Université Jean Monnet, INSERM, U 1059 SAINBIOSE, Saint-Etienne, 42023, France.
In this study, we investigated gene expression in vitro of human primary Aortic smooth muscle cells (AoSMCs) in response to 9% physiological dynamic stretch over a 4 to 72-h timeframe using RT-qPCR. AoSMC were derived from primary culture and were exposed to continuous cycles of stretch and relaxation at 1 Hz by a computer-controlled Flex Jr.™ Tension System.
View Article and Find Full Text PDFExosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats.
Stem Cell Res Ther
December 2024
National Colorectal Disease CenterNanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, Jiangsu, People's Republic of China.
Background: Complex perianal fistulas, challenging to treat and prone to recurrence, often require surgical intervention that may cause fecal incontinence and lower quality of life due to large surgical wounds and potential sphincter damage. Human umbilical cord-derived MSCs (hUC-MSCs) and their exosomes (hUCMSCs-Exo) may promote wound healing.
Methods: This study assessed the efficacy, mechanisms, and safety of these exosomes in treating complex perianal fistulas in SD rats.
MicroRNA-668 alleviates renal fibrosis through PPARα/PGC-1α pathway.
Eur J Med Res
December 2024
Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Background: The involvement of microRNA-668 (miR-668) in the onset and progression of renal fibrosis remains unclear. To this end, we aimed to explore the relevant mechanism of miR-668 in renal fibrosis.
Methods: C57BL/6 J male mice were randomly divided into sham-operated, unilateral ureteral obstruction (UUO), and UUO-fenofibrate groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!