AI Article Synopsis
- Redox signal transduction, particularly through the oxidative modification of protein thiols, is linked to various diseases and is becoming a key research focus.
- There is a lack of quick and specific methods for detecting protein thiols and their oxidative changes in living cells.
- This article reviews current chemical methods for detecting these modifications and explores future fluorescent probes that could enhance research on reactive cysteine proteomes and aid in early disease detection.
Article Abstract
Redox signal transduction, especially the oxidative modification of proein thiols, correlates with many diseases and becomes an expanding research area. However, there was rare method for quick and specific detection of protein thiols and their oxidative modification in living cells. In this article, we review the current chemical strategies for the detection and quantification of protein thiols and related cysteine oxidation. We also look into the future of the development of fluorescent probes for protein thiols and their potential application in the research of reactive cysteine proteomes and early detection of redox-related diseases.
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