Two new and one known ecdysteroids were identified in the methanolic extract of the roots of Serratula wolffii. The new compounds isolated were ponasterone A-22-apioside (1) and 3-epi-shidasterone (3), together with the known 3-epi-22-deoxy-20-hydroxyecdysone (2). The structures of compounds 1-3 were determined by extensive spectroscopic techniques, including one- and two-dimensional NMR methods.
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| http://dx.doi.org/10.1100/2012/651275 | DOI Listing |
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Novel ecdysteroids from Serratula wolffii.
ScientificWorldJournal
November 2012
Department of Pharmacognosy, University of Szeged, Eötvös utca 6, 6720 Szeged, Hungary.
Two new and one known ecdysteroids were identified in the methanolic extract of the roots of Serratula wolffii. The new compounds isolated were ponasterone A-22-apioside (1) and 3-epi-shidasterone (3), together with the known 3-epi-22-deoxy-20-hydroxyecdysone (2). The structures of compounds 1-3 were determined by extensive spectroscopic techniques, including one- and two-dimensional NMR methods.
View Article and Find Full Text PDFStructure and stereochemistry of novel ecdysteroids from the roots of Serratula wolffii.
Magn Reson Chem
May 2010
Department of Pharmaceutical Chemistry, Semmelweis University, Högyes Endre utca 9, H-1092 Budapest, Hungary.
Three new natural ecdysteroids viz. 22-dehydro-20-deoxy-ajugasterone C (1), 1-hydroxy-22-deoxy-20,21-didehydro-ecdysone (2) and 22-deoxy-20,21-didehydro-ecdysone (3) were isolated from the methanol extract of the roots of Serratula wolffii. The structures of compounds 1-3 were established by various spectroscopic techniques, including one- and two-dimensional NMR, circular dichroism and mass spectroscopic methods.
View Article and Find Full Text PDFThree new steroids from the roots of Serratula wolffii.
Steroids
October 2007
Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt Gellért tér 4, H-1111, Budapest, Hungary.
Investigation of the methanol extract of the roots of Serratula wolffii resulted in an ecdysone-related compound, 2beta,3beta,20R,22R,25-pentahydroxy-5beta-cholest-6,8(14)-dien (1), a new ecdysteroid, 24-methylene-shidasterone (2), the known compound stachysterone B (3) and its 14,15-alpha-epoxide (4), a novel natural product. The structures of compounds 1-4 were established by spectral analysis ((1)H NMR, (13)C NMR, COSY, NOESY, HMQC, HMQC-TOCSY and HMBC).
View Article and Find Full Text PDF[Ecdysteroid sources in the Carpathian basin. 11-hydroxy substituted ecdysteroids from the Serratula wolffii Andrae].
Acta Pharm Hung
September 2007
SZTE GYTK Farmakognóziai Intézet, Szeged, Eötvös u. 6.-6720.
Seven ecdysteroids have been isolated from the methanolic extract of the herb Serratula wolffii Andrae. The isolation process involved the removal of polar and apolar contaminants, and also included the separation of the target ecdysteroids from each other by using combined chromatographic methods. Isolation of the pure compounds required a minimum of 2 and a maximum of 7 consecutive chromatographic steps with different selectivity.
View Article and Find Full Text PDFPreparative-scale chromatography of ecdysteroids of Serratula wolffli andrae.
J Chromatogr Sci
February 2007
Department of Pharmacognosy, University of Szeged, H-6720 Szeged Eötvös u.6., Hungary.
Numerous ecdysteroids are isolated from the herb of Serratula wolffii Andrae, a cultivated plant. The isolation procedure includes a variety of low-pressure liquid chromatography, thin-layer chromatography (TLC), gel chromatography, and high-performance liquid chromatography (HPLC) methods. The progress of separation is monitored by TLC, and the final proof of purity is carried out by HPLC.
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