The most important radioisotope for use in Nuclear Medicine is (99m)Tc, supplied in the form of a (99)Mo/(99m)Tc generator. After the supply crisis of (99)Mo starting in 2008 the availability of (99)Mo became a worldwide concern. The purpose of this work is to do a brief story of the availability of (99)Mo in the world followed by an overview of the production routes of (99)Mo and the generators technology.
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http://dx.doi.org/10.2174/1874471011205030178 | DOI Listing |
Appl Radiat Isot
December 2022
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
This work presents the thick target production yields of Tc, Tc, Tc, Tc, Tc and Mo radionuclides produced by 8.0-18.0MeV proton induced reactions on natural molybdenum targets.
View Article and Find Full Text PDFFront Chem
July 2022
Department of Chemistry, Biochemistry, and Pharmaceutical Sciences (DCBP), Faculty of Science, University of Bern, Bern, Switzerland.
The continuing rapid expansion of Tc diagnostic agents always calls for scaling up Tc production to cover increasing clinical demand. Nevertheless, Tc availability depends mainly on the fission-produced Mo supply. This supply is seriously influenced during renewed emergency periods, such as the past Mo production crisis or the current COVID-19 pandemic.
View Article and Find Full Text PDFNucl Med Rev Cent East Eur
May 2021
Raja Ramana Fellow, Trombay, 400 085 Mumbai, India.
Background: Few nuclear reactors in the world producing high specific activity (HSA) 99Mo using enriched 235U (HEU), are aging and are planned for shut down in the near future. Further, HEU will not be freely available, due to safeguards, and the technology for 99Mo from low-enriched 235U (LEU) is not yet widely accepted since 239Pu contamination in the product is an issue. Production of 99mTc from low specific activity (LSA) 99Mo obtained from 98Mo(n,)99Mo reaction in research reactor and 100Mo(,n)99Mo reaction in accelerator or directly from 100Mo(p,2n)99mTc nuclear reaction in cyclotron, has been explored [1].
View Article and Find Full Text PDFMolecules
December 2018
Legnaro National Laboratories, Italian National Institute for Nuclear Physics (LNL-INFN), Viale dell'Università 2, 35020 Legnaro PD, Italy.
Appl Radiat Isot
July 2018
Department of Astrophysics, University of New South Wales, Sydney, Australia.
Compact neutron generators can provide high flux of neutrons with energies ranging from thermal (0.025 eV) to 14 MeV. Recent measurements demonstrated high neutron yields from the D-Li fusion reaction at an interaction energy of 500 keV.
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